| Gene Symbol |
LPXN
|
| Entrez Gene |
9404
|
| Alt Symbol |
LDPL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leupaxin
|
| Other Description |
-
|
| Swissprots |
Q6FI07 Q53FW6 B4DV71 B2R8B4 O60711
|
| Accessions |
EAW73807 EAW73808 EAW73809 O60711 AA848029 AF062075 AAC16014 AK223165 BAD96885 AK299264 BAH12983 AK300955 BAG62583 AK301093 BAG62693 AK313306 BAG36111 BC007490 BC019035 AAH19035 BC034230 BP261314 BU688891 CR536531 CAG38768 DA363664 DQ892705 ABM83631 DQ895954 ABM86880 XM_006718750 XP_006718813 XM_011545388 XP_011543690 XM_011545389 XP_011543691 XM_011545390 XP_011543692 XM_011545391 XP_011543693 XM_011545392 XP_011543694 XM_011545393 XP_011543695 XM_011545394 XP_011543696 NM_001143995 NP_001137467 NM_001307951 NP_001294880 NM_004811 NP_004802
|
| Function |
Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.
|
| Subcellular Location |
Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B- cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.
|
| Tissue Specificity |
Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression. {ECO:0000269|PubMed:12674328, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331}.
|