MCF2L

Gene Symbol MCF2L
Entrez Gene 23263
Alt Symbol ARHGEF14, DBS, OST
Species Human
Gene Type protein-coding
Description MCF.2 cell line derived transforming sequence-like
Other Description DBL's big sister|MCF2 transforming sequence-like protein|guanine nucleotide exchange factor DBS
Swissprots A2A2X1 O15068 Q5VXT1 E9PDN8 Q8N679 Q765G9 B4DIL6 A2A3G8 Q765G8 B4DHD6 Q6ZWD4 A2A2X2 Q5JU56 A2A3G6
Accessions EAX09175 EAX09176 EAX09177 EAX09178 EAX09179 EAX09180 O15068 AB002360 BAA20817 AB116074 BAD08351 AB116075 BAD08352 AF086413 AK022184 AK057899 BAB71611 AK092739 AK094768 BAG52925 AK123267 AK295047 BAG58097 AK295670 BAG58528 AK307867 AK315969 BAH14340 AW241629 BC011853 AAH11853 BC020208 AAH20208 BC107066 AAI07067 BC107067 AAI07068 BX648279 CR988747 DA114166 DA313448 DA769805 DB476653 DQ892041 ABM82967 DQ895233 ABM86159 EF212235 XM_005268309 XP_005268366 XM_005268314 XP_005268371 XM_005268316 XP_005268373 XM_011537482 XP_011535784 XM_011537483 XP_011535785 XM_011537484 XP_011535786 XM_011537485 XP_011535787 XM_011537486 XP_011535788 XM_011537487 XP_011535789 XM_011537488 XP_011535790 XM_011537489 XP_011535791 XM_011537490 XP_011535792 XM_011537491 XP_011535793 XM_011537492 XP_011535794 XM_011537493 XP_011535795 NM_001112732 NP_001106203 NM_024979 NP_079255
Function Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42. {ECO:0000250, ECO:0000269|PubMed:15157669}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Dbs (C-7) - sc-376400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dbs (C-7): sc-376400. Western blot analysis of Dbs expression in non-transfected: sc-117752 (A) and human Dbs transfected: sc-159837 (B) 293T whole cell lysates.

Dbs (H-90) - sc-292414 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Dbs (D-15) - sc-26125 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Dbs (L-20) - sc-901 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dbs (L-20): sc-901. Western blot analysis of Dbs expression in non-transfected: sc-117752 (A) and human Dbs transfected: sc-159837 (B) 293T whole cell lysates.

Dbs (G-19) - sc-26126 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dbs (G-19): sc-26126. Western blot analysis of Dbs expression in mouse brain tissue extract (A) and Raji whole cell lysate (B).

Anti-ARHGEF14 antibody - ab96395 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ARHGEF14 antibody (ab96395) at 1/1000 dilutionLane 1 : Molt-4 whole cell lysateLane 2 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-ARHGEF14 antibody - ab57401 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ARHGEF14 antibody (ab57401) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human tonsil.

Anti-ARHGEF14 antibody - ab172425 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-ARHGEF14 antibody (ab172425) at 1/500 dilutionLane 1 : ARHGEF14 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-Mouse IgG

Anti-MCF2L / DBS Antibody (aa1048-1075, Biotin) - LS-C262835 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2L / DBS Antibody (aa1048-1075, FITC) - LS-C262837 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2L / DBS Antibody (aa1048-1075, AP) - LS-C262833 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2L / DBS Antibody (aa1048-1075, APC) - LS-C262834 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2L / DBS Antibody (aa1048-1075, Azide-free, HRP) - LS-C262836 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2L / DBS Antibody (aa1048-1075, PE) - LS-C262838 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2L / DBS Antibody (aa1048-1075) - LS-C322906 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2L / DBS Antibody (aa220-320, Azide-free) - LS-C327862 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-MCF2L / DBS Antibody (aa84-367) - LS-C186258 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: Molt-4 , B: Raji. 5% SDS PAGE. MCF2L / DBS antibody diluted at 1:1000.

Anti-MCF2L / DBS Antibody (clone 1D11) IHC-plus™ - LS-B4519 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1D11
Anti-MCF2L antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4519 concentration 5 ug/ml.

Anti-MCF2L / DBS Antibody (aa1049-1075) IHC-plus™ - LS-B9783 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-MCF2L / DBS antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9783 dilution 1:100.

MCF2L Antibody (1D11) - H00023263-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D11
Immunohistochemistry-Paraffin: MCF2L Antibody (1D11) [H00023263-M01] - Analysis of monoclonal antibody to MCF2L on formalin-fixed paraffin-embedded human tonsil. Antibody concentration 1 ug/ml.

MCF2L Antibody - NBP1-88823 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: MCF2L Antibody [NBP1-88823] - Staining of human cell line A-431 shows positivity in plasma membrane & cytoplasm.

MCF2L Antibody - NBP1-33422 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MCF2L Antibody [NBP1-33422] - Sample (30 ug of whole cell lysate) A: Molt-4 B: Raji 5% SDS PAGE; antibody diluted at 1:1000.

MCF2L Antibody - H00023263-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: MCF2L Antibody [H00023263-B01] - analysis of MCF2L expression in transfected 293T cell line by MCF2L MaxPab polyclonal antibody. Lane 1: MCF2L transfected lysate (108.24 KDa). Lane 2: Non-transfected lysate.

Anti-MCF2L (N-terminal) antibody produced in rabbit - SAB2701123 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MCF2L (N-terminal): <B>Cat. No. SAB2701123</B>: Western Blot analysis of MCF2L in extracts from <B>Lanes</B><BR/>A. MOLT4 <BR/>B. Raji using <B>Cat. No. SAB2701123</B> at a 1:1000 dilution.

Anti-MCF2L antibody produced in rabbit - HPA008614 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MCF2L: <B>Cat. No. HPA008614</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymph node shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction center.
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