| Gene Symbol | MCF2L |
|---|---|
| Entrez Gene | 23263 |
| Alt Symbol | ARHGEF14, DBS, OST |
| Species | Human |
| Gene Type | protein-coding |
| Description | MCF.2 cell line derived transforming sequence-like |
| Other Description | DBL's big sister|MCF2 transforming sequence-like protein|guanine nucleotide exchange factor DBS |
| Swissprots | A2A2X1 O15068 Q5VXT1 E9PDN8 Q8N679 Q765G9 B4DIL6 A2A3G8 Q765G8 B4DHD6 Q6ZWD4 A2A2X2 Q5JU56 A2A3G6 |
| Accessions | EAX09175 EAX09176 EAX09177 EAX09178 EAX09179 EAX09180 O15068 AB002360 BAA20817 AB116074 BAD08351 AB116075 BAD08352 AF086413 AK022184 AK057899 BAB71611 AK092739 AK094768 BAG52925 AK123267 AK295047 BAG58097 AK295670 BAG58528 AK307867 AK315969 BAH14340 AW241629 BC011853 AAH11853 BC020208 AAH20208 BC107066 AAI07067 BC107067 AAI07068 BX648279 CR988747 DA114166 DA313448 DA769805 DB476653 DQ892041 ABM82967 DQ895233 ABM86159 EF212235 XM_005268309 XP_005268366 XM_005268314 XP_005268371 XM_005268316 XP_005268373 XM_011537482 XP_011535784 XM_011537483 XP_011535785 XM_011537484 XP_011535786 XM_011537485 XP_011535787 XM_011537486 XP_011535788 XM_011537487 XP_011535789 XM_011537488 XP_011535790 XM_011537489 XP_011535791 XM_011537490 XP_011535792 XM_011537491 XP_011535793 XM_011537492 XP_011535794 XM_011537493 XP_011535795 NM_001112732 NP_001106203 NM_024979 NP_079255 |
| Function | Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42. {ECO:0000250, ECO:0000269|PubMed:15157669}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. |
Dbs CRISPR/Cas9 KO Plasmid (h) - sc-405698 from Santa Cruz Biotechnology
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Dbs HDR Plasmid (h) - sc-405698-HDR from Santa Cruz Biotechnology
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Dbs Double Nickase Plasmid (h) - sc-405698-NIC from Santa Cruz Biotechnology
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Dbs Double Nickase Plasmid (h2) - sc-405698-NIC-2 from Santa Cruz Biotechnology
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Dbs CRISPR Activation Plasmid (h) - sc-405698-ACT from Santa Cruz Biotechnology
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Dbs CRISPR Activation Plasmid (h2) - sc-405698-ACT-2 from Santa Cruz Biotechnology
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Dbs Lentiviral Activation Particles (h) - sc-405698-LAC from Santa Cruz Biotechnology
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Dbs Lentiviral Activation Particles (h2) - sc-405698-LAC-2 from Santa Cruz Biotechnology
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Dbs siRNA (h) - sc-41728 from Santa Cruz Biotechnology
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Dbs shRNA Plasmid (h) - sc-41728-SH from Santa Cruz Biotechnology
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Dbs shRNA (h) Lentiviral Particles - sc-41728-V from Santa Cruz Biotechnology
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MCF2L RNAi - H00023263-R01 from Novus Biologicals
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MISSION® esiRNA - EHU141631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13110 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13110 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01822 from Sigma-Aldrich
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MCF2L siRNA (Human) - CRH8134 from Cohesion Biosciences
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MCF2L RNAi - H00023263-R02 from Novus Biologicals
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MCF2L shRNA Plasmid (Human) - CHH8134 from Cohesion Biosciences
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MCF2L miRNA 3'UTR clone - MiUTR3H-10641 from Creative biogene
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MCF2L miRNA 3'UTR clone - MiUTR3H-10642 from Creative biogene
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