| Gene Symbol |
SUPT5H
|
| Entrez Gene |
6829
|
| Alt Symbol |
SPT5, SPT5H, Tat-CT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of Ty 5 homolog (S. cerevisiae)
|
| Other Description |
DRB sensitivity-inducing factor 160 kDa subunit|DRB sensitivity-inducing factor large subunit|DSIF large subunit|DSIF p160|Tat-cotransactivator 1 protein|hSPT5|transcription elongation factor SPT5
|
| Swissprots |
Q99639 O43279 Q59G52 O00267
|
| Accessions |
CCQ43204 EAW56896 EAW56897 EAW56898 EAW56899 EAW56900 O00267 AB000516 BAA24075 AB209257 BAD92494 AF040253 AAD02179 AF052165 AK091476 AK295137 BAG58160 AK296117 BAG58866 AK302954 BAG64109 AK303480 BAG64516 BC024203 AAH24203 BP199253 DB064517 DB097498 DQ896795 ABM87794 U56402 AAC51102 Y12790 CAA73326 XM_005259183 XP_005259240 XM_006723337 XP_006723400 NM_001111020 NP_001104490 NM_001130824 NP_001124296 NM_001130825 NP_001124297 NM_003169 NP_003160
|
| Function |
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptio
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10075709}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:8975720}.
|