SUPT5H

Gene Symbol SUPT5H
Entrez Gene 6829
Alt Symbol SPT5, SPT5H, Tat-CT1
Species Human
Gene Type protein-coding
Description suppressor of Ty 5 homolog (S. cerevisiae)
Other Description DRB sensitivity-inducing factor 160 kDa subunit|DRB sensitivity-inducing factor large subunit|DSIF large subunit|DSIF p160|Tat-cotransactivator 1 protein|hSPT5|transcription elongation factor SPT5
Swissprots Q99639 O43279 Q59G52 O00267
Accessions CCQ43204 EAW56896 EAW56897 EAW56898 EAW56899 EAW56900 O00267 AB000516 BAA24075 AB209257 BAD92494 AF040253 AAD02179 AF052165 AK091476 AK295137 BAG58160 AK296117 BAG58866 AK302954 BAG64109 AK303480 BAG64516 BC024203 AAH24203 BP199253 DB064517 DB097498 DQ896795 ABM87794 U56402 AAC51102 Y12790 CAA73326 XM_005259183 XP_005259240 XM_006723337 XP_006723400 NM_001111020 NP_001104490 NM_001130824 NP_001124296 NM_001130825 NP_001124297 NM_003169 NP_003160
Function Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptio
Subcellular Location Nucleus {ECO:0000269|PubMed:10075709}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:8975720}.

SUPT5H - MBS1271744 from MyBioSource

Species Human
Accession BC024203

Human SUPT5H cDNA clone(NM_001130824.1) - CDFH018998 from Creative Biomart

Species Human
Accession NM_001130824.1

Human SUPT5H cDNA clone(NM_001130825.1) - CDFH018999 from Creative Biomart

Species Human
Accession NM_001130825.1

Human SUPT5H ORF Clone(NM_001111020.2) - CDCR347802 from Creative Biomart

Species Human
Accession NM_001111020.2

Human SUPT5H ORF Clone(NM_001111020.2) - CDCR347803 from Creative Biomart

Species Human
Accession NM_001111020.2

Human SUPT5H ORF Clone(NM_001130824.1) - CDCR349657 from Creative Biomart

Species Human
Accession NM_001130824.1

Human SUPT5H ORF Clone(NM_001130824.1) - CDCR349658 from Creative Biomart

Species Human
Accession NM_001130824.1

Human SUPT5H ORF Clone(NM_001130825.1) - CDCR349659 from Creative Biomart

Species Human
Accession NM_001130825.1

Human SUPT5H ORF Clone(NM_001130825.1) - CDCR349661 from Creative Biomart

Species Human
Accession NM_001130825.1

human SUPT5H ORF clone - CDCH087638 from Creative Biomart

Species Human
Accession NM_001111020

human SUPT5H ORF clone - CDCH087639 from Creative Biomart

Species Human
Accession NM_001111020

human SUPT5H ORF clone - CDCH087640 from Creative Biomart

Species Human
Accession NM_001111020

human SUPT5H ORF clone - CDCH087641 from Creative Biomart

Species Human
Accession NM_001111020

Human SUPT5H ORF Clone(NM_001130824.1) - CDCR349657 from Creative biogene

Species Human

human SUPT5H ORF clone (NM_001130825.1) - CDCH087640 from Creative biogene

Species Human

Human SUPT5H ORF Clone (BC024203) - CDCS407617 from Creative biogene

Species Human
Accession O00267

Human SUPT5H cDNA Clone(NM_001130824.1) - CDFH018998 from Creative biogene

Species Human

Human SUPT5H cDNA Clone(NM_001130825.1) - CDFH018999 from Creative biogene

Species Human
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