| Gene Symbol |
SART3
|
| Entrez Gene |
9733
|
| Alt Symbol |
DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb)
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
squamous cell carcinoma antigen recognized by T cells 3
|
| Other Description |
SART-3|hSART-3|p110 nuclear RNA-binding protein|squamous cell carcinoma antigen recognized by T-cells 3|tat-interacting protein of 110 kDa
|
| Swissprots |
Q2M2H0 A8K2E4 Q96J95 Q8IUS1 Q15020 Q58F06 B7ZKM0
|
| Accessions |
EAW97816 EAW97817 Q15020 AB020880 BAA78384 AB073647 AF387506 AAK69347 AI656011 AK225174 AK290209 BAF82898 AK299250 BAG61281 AK302332 BAG63664 AK304834 BAG65578 BC004547 BC015627 BC024279 BC032601 AAH32601 BC041638 AAH41638 BC093784 AAH93784 BC103706 AAI03707 BC111983 AAI11984 BC143253 AAI43254 BQ231651 CN349201 CR933631 D63879 BAA09929 DA391623 XM_005269241 XP_005269298 XM_011539026 XP_011537328 NM_014706 NP_055521
|
| Function |
U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). Ma
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:10463607, ECO:0000269|PubMed:11959860, ECO:0000269|PubMed:12578909}. Nucleus, Cajal body {ECO:0000269|PubMed:12578909}. Nucleus speckle {ECO:0000269|PubMed:11959860}. Cytoplasm {ECO:0000269|PubMed:10463607, ECO:0000269|PubMed:11959860}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11959860}.
|