ULK3

Gene Symbol ULK3
Entrez Gene 25989
Alt Symbol -
Species Human
Gene Type protein-coding
Description unc-51 like kinase 3
Other Description serine/threonine-protein kinase ULK3
Swissprots D3DW68 Q6PHR2 B4DFT0 B2RXK3 B4DRQ7 Q9UFS4 Q9NPN5
Accessions EAW99302 EAW99304 EAW99305 Q6PHR2 AI677802 AK075047 AK293181 BAG56723 AK293650 BAG57102 AK294241 BAG57537 AK294245 BAG57541 AK294251 BAG57547 AK298879 BAG60995 AK299380 BAG61369 AK316102 BAH14473 AL117482 CAB55955 AL360256 CAB96176 BC036117 BC048289 BC056423 BC157884 AAI57885 BI829133 BQ927030 XM_005254289 XP_005254346 XM_011521445 XP_011519747 XR_931789 XR_931790 XR_931791 XR_931792 NM_001099436 NP_001092906 NM_001284364 NP_001271293 NM_001284365 NP_001271294 NR_104307 NR_104308 NR_104309
Function Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745}. Note=Localizes to pre-autophagosomal structure during cellular senescence.
Tissue Specificity Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord. {ECO:0000269|PubMed:19878745}.
Top Pathways Regulation of autophagy, mTOR signaling pathway

ULK3 (C-13) - sc-137897 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
ULK3 (C-13): sc-137897. Western blot analysis of ULK3 expression in human heart (A) and human testis (B) tissue extracts.

ULK3 (S-12) - sc-137899 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

ULK3 (N-24) - sc-130614 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
ULK3 (N-24): sc-130614. Western blot analysis of ULK3 expression in human heart tissue extract.

Anti-ULK3 antibody - ab81092 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-ULK3 antibody - ab111195 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111195 at 1/50 dilution staining ULK3 in paraffin-embedded Human Breast carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-ULK3 antibody - ab67020 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-ULK3 antibody (ab67020) at 1/500 dilutionLane 1 : Transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-ULK3 antibody - ab191572 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-ULK3 antibody (ab191572) at 0.5 µg/mlLane 2 : Anti-ULK3 antibody (ab191572) at 1 µg/mlLane 1 : Human brain tissue lysateLane 2 : Human brain tissue lysateLysates/proteins at 15 µg per lane.

Anti-ULK3 antibody [EP4889] - ab133605 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP4889
All lanes : Anti-ULK3 antibody [EP4889] (ab133605) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : ULK3 transfected 293T cell lysate Lysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-ULK3 antibody [EPR4888] - ab124947 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4888
All lanes : Anti-ULK3 antibody [EPR4888] (ab124947) at 1/1000 dilutionLane 1 : Human heart lysateLane 2 : Human testis lysateLane 3 : Human fetal kidney lysateLane 4 : LnCaP cell lysateLane 5 : 293T cell lysateLysates/proteins at 10 µg per lane.Secondarystandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-ULK3 Antibody (Internal) IHC-plus™ - LS-B10169 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ULK3 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10169 concentration 10 ug/ml.

Anti-ULK3 Antibody (C-Terminus) - LS-C154921 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ULK3 Antibody (aa347-375, AP) - LS-C218337 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ULK3 Antibody (aa347-375, APC) - LS-C218338 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ULK3 Antibody (aa141-190) - LS-C199708 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma tissue, using ULK3 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-ULK3 Antibody (aa347-375, Biotin) - LS-C218339 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ULK3 Antibody (aa347-375, FITC) - LS-C218340 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ULK3 Antibody (aa347-375, Azide-free, HRP) - LS-C218341 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ULK3 Antibody (aa347-375, PE) - LS-C218342 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ULK3 Antibody (aa324-373) - LS-C116921 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ULK3 antibody LS-C116921 Western blot of Jurkat lysate.

Anti-ULK3 Antibody (Internal, AP) - LS-C218343 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ULK3 Antibody (Internal, APC) - LS-C218344 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ULK3 Antibody (Internal, FITC) - LS-C218346 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ULK3 Antibody (Internal, Biotin) - LS-C218345 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ULK3 Antibody (Internal, clone EP4889) - LS-C139014 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP4889
IHC of paraffin-embedded human colon tissue using anti-ULK3 antibody.

Anti-ULK3 Antibody (Internal, Azide-free, HRP) - LS-C218347 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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