ULK3

Gene Symbol	ULK3
Entrez Gene	25989
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	unc-51 like kinase 3
Other Description	serine/threonine-protein kinase ULK3
Swissprots	D3DW68 Q6PHR2 B4DFT0 B2RXK3 B4DRQ7 Q9UFS4 Q9NPN5
Accessions	EAW99302 EAW99304 EAW99305 Q6PHR2 AI677802 AK075047 AK293181 BAG56723 AK293650 BAG57102 AK294241 BAG57537 AK294245 BAG57541 AK294251 BAG57547 AK298879 BAG60995 AK299380 BAG61369 AK316102 BAH14473 AL117482 CAB55955 AL360256 CAB96176 BC036117 BC048289 BC056423 BC157884 AAI57885 BI829133 BQ927030 XM_005254289 XP_005254346 XM_011521445 XP_011519747 XR_931789 XR_931790 XR_931791 XR_931792 NM_001099436 NP_001092906 NM_001284364 NP_001271293 NM_001284365 NP_001271294 NR_104307 NR_104308 NR_104309
Function	Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745}. Note=Localizes to pre-autophagosomal structure during cellular senescence.
Tissue Specificity	Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord. {ECO:0000269|PubMed:19878745}.
Top Pathways	Regulation of autophagy, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ULK3 full length protein - ab101548 from Abcam Category Protein Prices $302.00, $410.00 Sizes 5 µg, 10 µg Source Baculovirus Species Human

Human ULK3 full length protein - ab153259 from Abcam Category Protein Source Wheat germ Species Human

Human ULK3 protein fragment - ab153260 from Abcam Category Protein Source Wheat germ Species Human

ULK3 Antibody Blocking Peptide - LS-E2451 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK3 Antibody Blocking Peptide - LS-E3160 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK3 Antibody Blocking Peptide - LS-E27783 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK3 Antibody Blocking Peptide - LS-E27784 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK3 Antibody Blocking Peptide - LS-E21579 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK3 Antibody Blocking Peptide - LS-E9504 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK3 Partial Recombinant Protein - H00025989-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ULK3 Protein - H00025989-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ULK3-Antibody-C-term-Blocking-peptide - BP13473b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ULK3-Antibody-N-term-Blocking-Peptide - BP8115a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ULK3 Peptide - AC21-2595-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Unc-51-like kinase 3 (ULK3) - H00025989-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Unc-51-like kinase 3 (ULK3) - H00025989-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Unc-51-like kinase 3 (ULK3) - H00025989-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Unc-51-like kinase 3 (ULK3) - H00025989-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Unc-51-like kinase 3 (ULK3) - P5660 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

Ulk3 Peptide - 42-906P from ProSci Category Peptide

ULK3 Peptide - 7585P from ProSci Category Peptide Species Human

ULK3 Peptide - 42-905P from ProSci Category Peptide Species Human

ULK3 fusion protein - Ag15094 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human ULK3, His-tagged - ULK3-31667TH from Creative Biomart Category Protein Source Baculovirus

Recombinant Human ULK3, His-tagged - ULK3-3593H from Creative Biomart Category Protein Source E.coli Species Human

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