| Gene Symbol | CYP8B1 |
|---|---|
| Entrez Gene | 1582 |
| Alt Symbol | CP8B, CYP12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 8, subfamily B, polypeptide 1 |
| Other Description | 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1|sterol 12-alpha-hydroxylase |
| Swissprots | O75958 Q6NWT3 Q9UNU6 Q6NWT2 B2RCY3 |
| Accessions | AAD19877 EAW64682 Q9UNU6 AF090318 AAC63037 AK310784 AK315330 BAG37730 BC067434 AAH67434 BC067441 AAH67441 BC067442 AAH67442 BC067443 BC067444 AAH67444 NM_004391 NP_004382 |
| Function | Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. |
| Tissue Specificity | Liver. |
| Top Pathways | Primary bile acid biosynthesis, PPAR signaling pathway |