| Gene Symbol |
CYP8B1
|
| Entrez Gene |
1582
|
| Alt Symbol |
CP8B, CYP12
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 8, subfamily B, polypeptide 1
|
| Other Description |
7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1|sterol 12-alpha-hydroxylase
|
| Swissprots |
O75958 Q6NWT3 Q9UNU6 Q6NWT2 B2RCY3
|
| Accessions |
AAD19877 EAW64682 Q9UNU6 AF090318 AAC63037 AK310784 AK315330 BAG37730 BC067434 AAH67434 BC067441 AAH67441 BC067442 AAH67442 BC067443 BC067444 AAH67444 NM_004391 NP_004382
|
| Function |
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Liver.
|
| Top Pathways |
Primary bile acid biosynthesis, PPAR signaling pathway
|