CYP8B1

Gene Symbol CYP8B1
Entrez Gene 1582
Alt Symbol CP8B, CYP12
Species Human
Gene Type protein-coding
Description cytochrome P450, family 8, subfamily B, polypeptide 1
Other Description 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1|sterol 12-alpha-hydroxylase
Swissprots O75958 Q6NWT3 Q9UNU6 Q6NWT2 B2RCY3
Accessions AAD19877 EAW64682 Q9UNU6 AF090318 AAC63037 AK310784 AK315330 BAG37730 BC067434 AAH67434 BC067441 AAH67441 BC067442 AAH67442 BC067443 BC067444 AAH67444 NM_004391 NP_004382
Function Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Tissue Specificity Liver.
Top Pathways Primary bile acid biosynthesis, PPAR signaling pathway

CYP8B1 (H-46) - sc-367469 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CYP8B1 (M15-P3B7) - sc-101387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CYP8B1 (M15-P3B7): sc-101387. Western blot analysis of CYP8B1 expression in human liver microsomes.

CYP8B1 (P-18) - sc-23515 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CYP8B1 antibody - ab129845 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CYP8B1 antibody (ab129845) at 1/500 dilutionLane 1 : 293 cell extractLane 2 : 293 cell extract with synthesized peptide

Anti-CYP8B1 antibody - ab191910 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CYP8B1 antibody (ab191910)Lane 1 : HEK293T whole cell lysateLane 2 : RAW 264.7 whole cell lysateLane 3 : H9C2 whole cell lysate

Anti-CYP8B1 antibody - C-terminal - ab175843 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CYP8B1 antibody - C-terminal (ab175843) at 1/1000 dilution + K562 cell line lysate at 35 µg

Anti-CYP8B1 Antibody (aa357-406) - LS-C291865 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP8B1 Antibody (aa416-461) - LS-C313999 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP8B1 Antibody (aa219-268) - LS-C135722 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CYP8B1 antibody LS-C135722 Western blot of HepG2 cell lysate.

Anti-CYP8B1 Antibody - LS-C341074 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP8B1 Antibody (aa472-501) - LS-C167247 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with CYP8B1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

CYP8B1 Antibody - NBP2-29939 from Novus Biologicals

Prices $329.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CYP8B1 Antibody [NBP2-29939] - Western blot analysis of (C-term) (NBP2-29939) in K562 cell line lysates (35ug/lane). CYP8B1 (arrow) was detected using the purified Pab.

CYP8B1 Antibody - NBP1-68884 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CYP8B1 Antibody [NBP1-68884] - HepG2 cell lysate, concentration 0.2-1 ug/ml.

Anti-CYP8B1 antibody produced in rabbit - SAB2107498 from Sigma-Aldrich

Prices $341.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CYP8B1: <B>Cat. No. SAB2107498</B>: Western blot analysis of CYP8B1 with CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) antibody against the middle region of CYP8B1 (50 μg) antibody at 1.0 μg/mL.

ANTI-CYP8B1 (C-TERM) antibody produced in rabbit - SAB1301232 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>CYP8B1 (C-term): <B>Cat. No. SAB1301232</B>: CYP8B1 in Human hepatocarcinoma tissue with CYP8B1 antibody (C-term) at 5 μg/mL.

CYP8B1 antibody - middle region (ARP60138_P050) - ARP60138_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CYP8B1-Antibody-C-term- - AP8787b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of CYP8B1 Antibody (C-term) (Cat. #AP8787b) in K562 cell line lysates (35ug/lane). CYP8B1 (arrow) was detected using the purified Pab.

CYP8B1 Antibody - C-terminal region (OAAB05384) - OAAB05384 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

CYP8B1 antibody, C-term - GTX81025 from GeneTex

Prices $319.00
Sizes 400 μl
Host Rabbit
Clonality Polyclonal
Anti-CYP8B1 antibody, C-term used in Flow cytometry/FACS. GTX81025

CYP8B1 Antibody (OAAF04623) - OAAF04623 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Cytochrome P450 8B1 Antibody (OAAF06293) - OAAF06293 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Cytochrome P450 8B1 antibody - orb126858 from Biorbyt

Prices $85.00, $255.00, $425.00
Sizes 25 μg (Trial Size), 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells using Cytochrome P450 8B1 antibody

Anti -CYP8B1 (Cytochrome P450, Family 8, Subfamily B, Polypeptide 1) - 217890 from USBiological Life Science

Host Mouse
Clonality Monoclonal
Clone M15-P3B7
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