GLI1
| Gene Symbol | GLI1 |
|---|---|
| Entrez Gene | 2735 |
| Alt Symbol | GLI |
| Species | Human |
| Gene Type | protein-coding |
| Description | GLI family zinc finger 1 |
| Other Description | GLI-Kruppel family member GLI1|glioma-associated oncogene 1|glioma-associated oncogene homolog 1 (zinc finger protein)|oncogene GLI|zinc finger protein GLI1 |
| Swissprots | F5H6H8 D0EUY3 Q8TDN9 E9PQQ9 P08151 |
| Accessions | AAM13391 BAN82437 EAW97013 P08151 AB239135 BAG16751 AB239136 AB239328 AB558490 BAN82438 AK297899 BAG60219 BC013000 AAH13000 GQ890670 ACX35434 X07384 CAA30297 XM_005268799 XP_005268856 XM_011538189 XP_011536491 XM_011538190 XP_011536492 NM_001160045 NP_001153517 NM_001167609 NP_001161081 NM_005269 NP_005260 |
| Function | Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1. |
| Tissue Specificity | Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. {ECO:0000269|PubMed:19878745}. |
| Top Pathways | Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway |
GLI-1 CRISPR/Cas9 KO Plasmid (h) - sc-400266 from Santa Cruz Biotechnology
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GLI-1 HDR Plasmid (h) - sc-400266-HDR from Santa Cruz Biotechnology
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GLI-1 Double Nickase Plasmid (h) - sc-400266-NIC from Santa Cruz Biotechnology
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GLI-1 Double Nickase Plasmid (h2) - sc-400266-NIC-2 from Santa Cruz Biotechnology
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GLI-1 CRISPR Activation Plasmid (h) - sc-400266-ACT from Santa Cruz Biotechnology
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GLI-1 CRISPR Activation Plasmid (h2) - sc-400266-ACT-2 from Santa Cruz Biotechnology
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GLI-1 Lentiviral Activation Particles (h) - sc-400266-LAC from Santa Cruz Biotechnology
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GLI-1 Lentiviral Activation Particles (h2) - sc-400266-LAC-2 from Santa Cruz Biotechnology
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GLI-1 siRNA (h) - sc-37911 from Santa Cruz Biotechnology
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GLI-1 shRNA Plasmid (h) - sc-37911-SH from Santa Cruz Biotechnology
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GLI-1 shRNA (h) Lentiviral Particles - sc-37911-V from Santa Cruz Biotechnology
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GLI-1 RNAi - H00002735-R01 from Novus Biologicals
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MISSION® esiRNA - EHU026341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1420 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1418 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1419 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1419 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1418 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1420 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01012 from Sigma-Aldrich
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GLI1 siRNA (Human) - CRH1819 from Cohesion Biosciences
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GLI1 - MBS8208749 from MyBioSource
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shRNA set against Human GLI1 (NM_005269.2) - SHH301738 from Creative biogene
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Human GLI1 siRNA - orb262321 from Biorbyt
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GLI1 shRNA Plasmid (Human) - CHH1819 from Cohesion Biosciences
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