| Gene Symbol | AQP2 |
|---|---|
| Entrez Gene | 359 |
| Alt Symbol | AQP-CD, WCH-CD |
| Species | Human |
| Gene Type | protein-coding |
| Description | aquaporin 2 (collecting duct) |
| Other Description | ADH water channel|AQP-2|aquaporin-2|aquaporin-CD|collecting duct water channel protein|water channel protein for renal collecting duct|water-channel aquaporin 2 |
| Swissprots | P41181 Q9UD68 |
| Accessions | AAD14825 AAD38692 AAK55747 BAA06632 CAA82627 EAW58109 P41181 AI792401 AK055824 AK225940 BC042496 AAH42496 CR542024 CAG46821 S73196 AAB31999 S73197 AAB31998 NM_000486 NP_000477 |
| Function | Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. |
| Subcellular Location | Apical cell membrane {ECO:0000269|PubMed:12194985}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12194985}; Multi- pass membrane protein {ECO:0000269|PubMed:12194985}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12194985}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985}. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated. |
| Tissue Specificity | Expressed in renal collecting tubules. |
| Top Pathways | Vasopressin-regulated water reabsorption |