| Gene Symbol |
AQP2
|
| Entrez Gene |
359
|
| Alt Symbol |
AQP-CD, WCH-CD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aquaporin 2 (collecting duct)
|
| Other Description |
ADH water channel|AQP-2|aquaporin-2|aquaporin-CD|collecting duct water channel protein|water channel protein for renal collecting duct|water-channel aquaporin 2
|
| Swissprots |
P41181 Q9UD68
|
| Accessions |
AAD14825 AAD38692 AAK55747 BAA06632 CAA82627 EAW58109 P41181 AI792401 AK055824 AK225940 BC042496 AAH42496 CR542024 CAG46821 S73196 AAB31999 S73197 AAB31998 NM_000486 NP_000477
|
| Function |
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
|
| Subcellular Location |
Apical cell membrane {ECO:0000269|PubMed:12194985}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12194985}; Multi- pass membrane protein {ECO:0000269|PubMed:12194985}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12194985}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985}. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
|
| Tissue Specificity |
Expressed in renal collecting tubules.
|
| Top Pathways |
Vasopressin-regulated water reabsorption
|