AQP2

Gene Symbol	AQP2
Entrez Gene	359
Alt Symbol	AQP-CD, WCH-CD
Species	Human
Gene Type	protein-coding
Description	aquaporin 2 (collecting duct)
Other Description	ADH water channel|AQP-2|aquaporin-2|aquaporin-CD|collecting duct water channel protein|water channel protein for renal collecting duct|water-channel aquaporin 2
Swissprots	P41181 Q9UD68
Accessions	AAD14825 AAD38692 AAK55747 BAA06632 CAA82627 EAW58109 P41181 AI792401 AK055824 AK225940 BC042496 AAH42496 CR542024 CAG46821 S73196 AAB31999 S73197 AAB31998 NM_000486 NP_000477
Function	Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:12194985}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12194985}; Multi- pass membrane protein {ECO:0000269|PubMed:12194985}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12194985}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985}. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
Tissue Specificity	Expressed in renal collecting tubules.
Top Pathways	Vasopressin-regulated water reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Aquaporin 2 full length protein - ab152191 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

AQP2 / Aquaporin 2 Antibody Blocking Peptide - LS-E16270 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Aquaporin-2 Protein - H00000359-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

AQP2 peptide - orb72339 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

Human AQP2 Protein - abx065447 from Abbexa Category Protein Source E.coli Species Human

Aquaporin-2 - H00000359-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Aquaporin-2 - H00000359-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Aquaporin-2 / AQP2 control peptide - AP09888CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

Aquaporin 2, Collecting Duct (AQP2), Human - 20-6846 from ARP American Research Products Category Protein Prices $499.00 Sizes 50 µg Source E.coli Species Human

AQP2 Peptide - 7621P from ProSci Category Peptide Species Human

AQP2 fusion protein - ag5701 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Aquaporin-2 (254-267), human - 86719 from NeoScientific Category Peptide Prices $47.00, $141.00, $390.00 Sizes 1 mg, 5 mg, 25 mg Species Human

Aquaporin-2 (255-271), rat - 86717 from NeoScientific Category Peptide Prices $108.00, $180.00 Sizes 5 mg, 10 mg Species Rat

Aquaporin-2 (255-271), human - 86718 from NeoScientific Category Peptide Prices $47.00, $141.00, $235.00 Sizes 1 mg, 5 mg, 10 mg Species Human

Recombinant Human AQP2, His-tagged, GST-tagged - AQP2-3593H from Creative Biomart Category Protein Source E. Coli Species Human

Recombinant Aquaporin 2, Collecting Duct (AQP2) - RPA580Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Aquaporin 2, Collecting Duct (AQP2) - RPA580Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Aquaporin 2 Blocking Peptide - CBP3777 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Pig, Sheep

AQP2 (R252) Peptide - BS1718P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Aquaporin 2, Collecting Duct (AQP2) - RPA580Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Aquaporin-2(AQP2) - CSB-YP001962HU CSB-EP001962HU CSB-BP001962HU CSB-MP001962HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Aquaporin-2 (254-267) - abx260199 from Abbexa Source Human Species Human

Aquaporin-2 (255-271) - abx260200 from Abbexa Source Human Species Human

Aquaporin 2, Collecting Duct (AQP2), Recombinant Protein - MBS2009210 from MyBioSource Category Protein Prices $240.00, $435.00, $625.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Aquaporin-2 (AQP2), Recombinant Protein - MBS1112859 from MyBioSource Category Protein Prices $1,165.00, $1,625.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast

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