SOCS3
| Gene Symbol | SOCS3 |
|---|---|
| Entrez Gene | 9021 |
| Alt Symbol | ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | suppressor of cytokine signaling 3 |
| Other Description | STAT-induced STAT inhibitor 3|cytokine-inducible SH2 protein 3 |
| Swissprots | O14543 O14509 |
| Accessions | EAW89521 EAW89522 O14543 AB004904 BAA22430 AB006967 BAA22537 AF159854 AAD42231 AK309756 AK314212 BAG36886 AM392896 CAL37774 AM393146 CAL38024 AM393491 CAL38368 AU134017 BC060858 AAH60858 BE048635 BE245649 BT019544 AAV38351 CR536497 CAG38736 CR541694 CAG46495 DA671124 NM_003955 NP_003946 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). {ECO:0000250}. |
| Tissue Specificity | Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. |
| Top Pathways | TNF signaling pathway, Prolactin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Herpes simplex infection |
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