SOCS3

Gene Symbol SOCS3
Entrez Gene 9021
Alt Symbol ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3
Species Human
Gene Type protein-coding
Description suppressor of cytokine signaling 3
Other Description STAT-induced STAT inhibitor 3|cytokine-inducible SH2 protein 3
Swissprots O14543 O14509
Accessions EAW89521 EAW89522 O14543 AB004904 BAA22430 AB006967 BAA22537 AF159854 AAD42231 AK309756 AK314212 BAG36886 AM392896 CAL37774 AM393146 CAL38024 AM393491 CAL38368 AU134017 BC060858 AAH60858 BE048635 BE245649 BT019544 AAV38351 CR536497 CAG38736 CR541694 CAG46495 DA671124 NM_003955 NP_003946
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus.
Top Pathways TNF signaling pathway, Prolactin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Herpes simplex infection

SOCS3 (L210) Antibody - 2932 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using SOCS3 (L210) Antibody (left) and SOCS3 Antibody #2923 (right).

SOCS3 Antibody - 2923 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using SOCS3 Antibody.

SOCS-3 (H-103) - sc-9023 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SOCS-3 (H-103): sc-9023. Immunofluorescence staining of methanol-fixed HeLa + IFN-γ cells showing cytoplasmic localization.

SOCS-3 (M-20) - sc-7009 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SOCS-3 (S-19) - sc-7010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SOCS-3 (6A463) - sc-73045 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SOCS-3 (6A463): sc-73045. Western blot analysis of SOCS-3 expression in human PBL (A) and A549 (B) whole cell lysates.

SOCS-3 (SO1) - sc-51699 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SOCS-3 (SO1): sc-51699. Western blot analysis of SOCS-3 expression in HeLa (A), IFN γ-treated HeLa (B), IL-6-treated HeLa (C) and human PBL (D) whole cell lysates.

Anti-SOCS3 antibody - ab3693 from Abcam

Prices $391.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Localization of ab3693 as the precipitated red signal, with a hematoxylin purple nuclear counterstain in cardiac myocytes.

Anti-SOCS3 antibody - ab92860 from Abcam

Prices $379.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SOCS3 antibody (ab92860) at 1/500 dilutionLane 1 : Mouse liver lysateLane 2 : Mouse muscle lysate

Anti-SOCS3 antibody [15F9] - ab119313 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 15F9
All lanes : Anti-SOCS3 antibody [15F9] (ab119313) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SOCS3 cDNALysates/proteins at 5 µg per lane.

Anti-SOCS3 antibody [5C2] - ab119806 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5C2
All lanes : Anti-SOCS3 antibody [5C2] (ab119806) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SOCS3Lysates/proteins at 5 µg per lane.

Anti-SOCS3 antibody [6F3] - ab119089 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6F3
All lanes : Anti-SOCS3 antibody [6F3] (ab119089) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SOCS3 cDNALysates/proteins at 5 µg per lane.developed using the ECL technique

Anti-SOCS3 antibody [SO1] - ab14939 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone SO1
ICC/IF image of ab14939 stained HeLa cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab14939, 5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-mouse IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-SOCS3 antibody - ab53984 from Abcam

Prices $379.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Ab53984 staining Human normal jejunum. Staining is localized to the cytoplasm.Left panel: with primary antibody at 4 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 AR buffer EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS), then incubated with primary antibody for 20 minutes, and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-SOCS3 antibody - ab723 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-SOCS3 antibody (ab723) at 5 µg/ml + MOLT-4 lysate (RIPA buffer, 30µg total protein per lane)Observed band size : 24 kDa (why is the actual band size different from the predicted?)

Anti-SOCS3 antibody, prediluted - ab53993 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal

Anti-SOCS3 Antibody (clone 8G3) - LS-C173025 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8G3
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SOCS3 mouse monoclonal antibody.

Anti-SOCS3 Antibody (clone 3B8) - LS-C173038 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B8
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.

Anti-SOCS3 Antibody (aa1-225) - LS-C314817 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SOCS3.

Anti-SOCS3 Antibody (clone 15F9) - LS-C173037 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 15F9
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SOCS3 mouse monoclonal antibody.

Anti-SOCS3 Antibody - LS-C331102 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of K562 cells tissue, using SOCS3 antibody.

Anti-SOCS3 Antibody (C-Terminus) IHC-plus™ - LS-B3373 from LifeSpan Bioscience

Prices $395.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Anti-SOCS3 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3373 concentration 10 ug/ml.

Anti-SOCS3 Antibody - LS-C331075 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of K562 cell lysate using SOCS3 antibody.

Anti-SOCS3 Antibody (clone 3D3) - LS-C173003 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D3
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SOCS3 mouse monoclonal antibody.

Anti-SOCS3 Antibody (C-Terminus) - LS-C33939 from LifeSpan Bioscience

Prices $285.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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