SOCS3

Gene Symbol	SOCS3
Entrez Gene	9021
Alt Symbol	ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3
Species	Human
Gene Type	protein-coding
Description	suppressor of cytokine signaling 3
Other Description	STAT-induced STAT inhibitor 3|cytokine-inducible SH2 protein 3
Swissprots	O14543 O14509
Accessions	EAW89521 EAW89522 O14543 AB004904 BAA22430 AB006967 BAA22537 AF159854 AAD42231 AK309756 AK314212 BAG36886 AM392896 CAL37774 AM393146 CAL38024 AM393491 CAL38368 AU134017 BC060858 AAH60858 BE048635 BE245649 BT019544 AAV38351 CR536497 CAG38736 CR541694 CAG46495 DA671124 NM_003955 NP_003946
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). {ECO:0000250}.
Tissue Specificity	Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus.
Top Pathways	TNF signaling pathway, Prolactin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SOCS3 full length protein - ab131811 from Abcam Category Protein Source Wheat germ Species Human

Human SOCS3 full length protein - ab177638 from Abcam Category Protein Source E. coli Species Human

Human SOCS3 peptide - ab16199 from Abcam Category Peptide

Human SOCS3 peptide - ab22776 from Abcam Category Peptide Species Human

SOCS3 Antibody Blocking Peptide - LS-E25197 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SOCS-3 Protein - H00009021-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SOCS3 blocking peptide - GTX89907-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Human ATOD4 protein - orb84518 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source E. coli Species Human

SOCS3 protein (His tag) - 80R-3722 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

SOCS3 Blocking Peptide - abx063536 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Sheep

SOCS3 Peptide - AC21-0018-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SOCS3 / CIS3 (1-225, His-tag) - AR51409PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

SOCS3 / CIS3 (1-225, His-tag) - AR51409PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

SOCS3 / CIS3 - H00009021-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SOCS3 / CIS3 - H00009021-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SOCS3 / CIS3 control peptide - AP10328CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

SOCS3, 1-225aa Human, His tag, E.coli - 01-P2589 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

SOCS3 Peptide - 46-409P from ProSci Category Peptide Species Human

SOCS3 fusion protein - Ag5386 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SOCS3 fusion protein - Ag5170 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SOCS3, Trx & His tagged - SOCS3-3895H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Suppressor Of Cytokine Signaling 3, GST-tagged - SOCS3-6941H from Creative Biomart Category Protein Species Human

Recombinant Human SOCS3, His-tagged - SOCS3-5093H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human SOCS3, His-tagged - SOCS3-2872H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human suppressor of cytokine signaling 3, His-tagged - SOCS3-492H from Creative Biomart Category Protein Source E.coli Species Human

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