| Gene Symbol |
NRG2
|
| Entrez Gene |
9542
|
| Alt Symbol |
DON1, HRG2, NTAK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuregulin 2
|
| Other Description |
divergent of neuregulin-1|neural- and thymus-derived activator for ErbB kinases|pro-NRG2|pro-neuregulin-2, membrane-bound isoform
|
| Swissprots |
O14511
|
| Accessions |
AAF28848 AAF28849 AAF28850 AAF28851 AAF28852 AAF28853 EAW62078 EAW62080 EAW62081 EAW62082 EAW62083 EAW62084 EAW62085 EAW62086 EAW62087 O14511 AB005060 BAA23417 AI271427 AK124504 BAG54044 BC103983 AAI03984 BC103984 AAI03985 BC114333 AAI14334 BC114334 AAI14335 BC166615 AAI66615 DA090538 U92987 XM_005268533 XP_005268590 XM_006714808 XP_006714871 XM_006714810 XP_006714873 XM_011537710 XP_011536012 XM_011537711 XP_011536013 XM_011537712 XP_011536014 XM_011537713 XP_011536015 XR_944342 NM_001184935 NP_001171864 NM_004883 NP_004874 NM_013981 NP_053584 NM_013982 NP_053585 NM_013983 NP_053586 NM_013984 NM_013985
|
| Function |
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
|
| Subcellular Location |
Pro-neuregulin-2, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.
|
| Tissue Specificity |
Restricted to the cerebellum in the adult.
|
| Top Pathways |
ErbB signaling pathway
|
![Western Blot: Neuregulin-2 Overexpression Lysate (Adult Normal) [NBP2-10339] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Neuregulin-2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1248_Neuregulin-2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10339-img0001.jpg)