Gene Symbol | NRG2 |
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Entrez Gene | 9542 |
Alt Symbol | DON1, HRG2, NTAK |
Species | Human |
Gene Type | protein-coding |
Description | neuregulin 2 |
Other Description | divergent of neuregulin-1|neural- and thymus-derived activator for ErbB kinases|pro-NRG2|pro-neuregulin-2, membrane-bound isoform |
Swissprots | O14511 |
Accessions | AAF28848 AAF28849 AAF28850 AAF28851 AAF28852 AAF28853 EAW62078 EAW62080 EAW62081 EAW62082 EAW62083 EAW62084 EAW62085 EAW62086 EAW62087 O14511 AB005060 BAA23417 AI271427 AK124504 BAG54044 BC103983 AAI03984 BC103984 AAI03985 BC114333 AAI14334 BC114334 AAI14335 BC166615 AAI66615 DA090538 U92987 XM_005268533 XP_005268590 XM_006714808 XP_006714871 XM_006714810 XP_006714873 XM_011537710 XP_011536012 XM_011537711 XP_011536013 XM_011537712 XP_011536014 XM_011537713 XP_011536015 XR_944342 NM_001184935 NP_001171864 NM_004883 NP_004874 NM_013981 NP_053584 NM_013982 NP_053585 NM_013983 NP_053586 NM_013984 NM_013985 |
Function | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. |
Subcellular Location | Pro-neuregulin-2, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}. |
Tissue Specificity | Restricted to the cerebellum in the adult. |
Top Pathways | ErbB signaling pathway |
Human NRG2 protein fragment - ab152998 from Abcam
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Recombinant Human Neuregulin-2 Protein - H00009542-Q01 from Novus Biologicals
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Recombinant Human Neuregulin-2 Protein - H00009542-G01-10ug from Novus Biologicals
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Human Neuregulin 2 Protein - abx068239 from Abbexa
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Neuregulin 2 - H00009542-Q01-10 from Acris Antibodies
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Neuregulin 2 - H00009542-Q01-25 from Acris Antibodies
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Neuregulin 2 (NRG2), Human - 20-8402 from ARP American Research Products
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Recombinant Human Neuregulin 2 - NRG2-2695H from Creative Biomart
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Recombinant Human NRG2 - NRG2-266H from Creative Biomart
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Recombinant Human NRG2, GST-tagged - NRG2-267H from Creative Biomart
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Recombinant Neuregulin 2 (NRG2) - RPC172Hu01 from Uscn Life Science Inc.
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Recombinant Neuregulin 2 (NRG2) - RPC172Ra01 from Uscn Life Science Inc.
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Recombinant Neuregulin 2 (NRG2) - RPC172Hu01 from Cloud-clone
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Recombinant Human Pro-neuregulin-2, membrane-bound isoform(NRG2) - CSB-YP016078HU CSB-EP016078HU CSB-BP016078HU CSB-MP016078HU from Cusabio
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Neuregulin 2 (NRG2) - RPU143004 from Biomatik
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Pro-neuregulin-2, Recombinant Protein - MBS1164697 from MyBioSource
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Neuregulin-2 Protein - NBP1-87971PEP from Novus Biologicals
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NRG2-Antibody-C-term-Blocking-Peptide - BP6223a from Abgent, a WuXi AppTec company
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NRG2-Antibody-Center-Blocking-Peptide - BP6223b from Abgent, a WuXi AppTec company
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NRG2 Peptide, Human - M34GP10620H from Creative Peptides
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NRG2 Recombinant Protein (OPCA01761) - OPCA01761 from Aviva Systems Biology
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NRG2 Recombinant Protein (OPCA03096) - OPCA03096 from Aviva Systems Biology
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Recombinant Neuregulin 2 (NRG2) - RPU43004 from Biomatik
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NRG2 Recombinant Protein (OPCD05793) - OPCD05793 from Aviva Systems Biology
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Recombinant Human Pro-neuregulin-2, membrane-bound isoform(NRG2),partial - AP73733 from Signalway Antibody
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