| Gene Symbol |
DENND1B
|
| Entrez Gene |
163486
|
| Alt Symbol |
C1ORF18, C1orf218, FAM31B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DENN/MADD domain containing 1B
|
| Other Description |
DENN domain-containing protein 1B|connecdenn 2|family with sequence similarity 31, member B
|
| Swissprots |
Q8TBE6 Q6P3S1 Q5T3B8 Q9H774 Q8NDT1 Q9NXU2 Q5T3B9 Q6B0I8 B5MD89 Q5T3C1 D3PFD5 Q5TAI8
|
| Accessions |
CCQ43112 EAW91278 EAW91279 EAW91280 EAW91281 EAW91282 EAW91283 EAW91284 EAW91285 Q6P3S1 AI692985 AK000061 BAA90918 AK024832 BAB15024 AK091207 BAG52307 AK093982 AL831839 CAD38548 BC016588 AAH16588 BC022561 AAH22561 BC063456 BC063877 AAH63877 BC074735 AAH74735 BK006960 DAA12502 BP220095 DA495773 DQ892398 ABM83324 DQ895613 ABM86539 H19092 XM_005244931 XP_005244988 XM_005244932 XP_005244989 XM_006711192 XP_006711255 XM_006711193 XP_006711256 XM_006711194 XP_006711257 XM_011509246 XP_011507548 XM_011509247 XP_011507549 XM_011509248 XP_011507550 XM_011509249 XP_011507551 XM_011509250 XP_011507552 XM_011509251 XP_011507553 NM_001142795 NM_019049 NM_001195215 NP_001182144 NM_001195216 NP_001182145 NM_001300858 NP_001287787 NM_144977 NP_659414 NR_125340
|
| Function |
Guanine nucleotide exchange factor (GEF) for RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. May play a role in clathrin- mediated endocytosis. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T- cells as compared with naive T-cells. {ECO:0000269|PubMed:20032318}.
|