CSF1R
| Gene Symbol | CSF1R |
|---|---|
| Entrez Gene | 1436 |
| Alt Symbol | C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R |
| Species | Human |
| Gene Type | protein-coding |
| Description | colony stimulating factor 1 receptor |
| Other Description | CD115 antigen|CSF-1 receptor|FMS proto-oncogene|McDonough feline sarcoma viral (v-fms) oncogene homolog|macrophage colony stimulating factor I receptor|macrophage colony-stimulating factor 1 receptor|proto-oncogene c-Fms |
| Swissprots | D3DQG2 P07333 Q6LDY4 B5A955 Q86VW7 Q6LDW5 |
| Accessions | AAA35848 AAA35849 AAA88039 AAB51235 AAB51696 CAJ32237 CAV32774 CBX55881 CCA65436 EAW61749 EAW61750 P07333 AB208819 BAD92056 AI863331 AK294467 BAG57697 AK304491 BAG65300 BC047521 AAH47521 BC129939 AAI29940 BM562096 BM825705 BQ028933 BX648599 CD620053 DA219251 DR001419 EU826593 ACF47629 M14193 AAA35834 M25786 AAA58421 X03663 CAA27300 NM_001288705 NP_001275634 NM_005211 NP_005202 NR_109969 |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed in bone marrow and in differentiated blood mononuclear cells. |
| Top Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Endocytosis, Osteoclast differentiation, PI3K-Akt signaling pathway |
PathScan ® Total M-CSF Receptor Sandwich ELISA Kit - 13032 from Cell Signaling Technology
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PathScan ® Phospho-M-CSF Receptor (panTyr) Sandwich ELISA Kit - 13491 from Cell Signaling Technology
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PathScan ® Phospho-M-CSF Receptor (Tyr699) Sandwich ELISA Kit - 12946 from Cell Signaling Technology
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Human CSF1R / CD115 / FMS ELISA Kit (Sandwich ELISA) - LS-F2687 from LifeSpan Bioscience
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Mouse CSF1R / CD115 / FMS ELISA Kit (Sandwich ELISA) - LS-F2688 from LifeSpan Bioscience
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Human CSF1R / CD115 / FMS ELISA Kit (Sandwich ELISA) - LS-F649 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-CSF1R / CD115 / FMS (Tyr561) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1341 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-CSF1R / CD115 / FMS (Tyr723) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1258 from LifeSpan Bioscience
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Human CSF1R / CD115 / FMS ELISA Kit (Cell-Based ELISA) - LS-F1917 from LifeSpan Bioscience
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Human CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit - RAB0711 from Sigma-Aldrich
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Phosphotyrosine CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit - RAB0978 from Sigma-Aldrich
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CSF1R/M-CSFR BioAssay ELISA Kit, Human - 143784 from USBiological Life Science
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CSF1R/M-CSFR BioAssay ELISA Kit, Mouse - 143785 from USBiological Life Science
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Human Phospho-M-CSF R DuoSet IC Economy Pack - DYC3268E from R&D Systems
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Human Phospho-M-CSF R DuoSet IC ELISA - DYC3268-2 from R&D Systems
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Human Phospho-M-CSF R DuoSet IC, 5 Plate - DYC3268-5 from R&D Systems
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Human M-CSF R/CD115 DuoSet ELISA - DY329 from R&D Systems
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Human Total M-CSF R/CD115 DuoSet IC ELISA - DYC329-2 from R&D Systems
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M-CSFR ELISA Kit (Human) : 96 Wells (OKAG00152) - OKAG00152 from Aviva Systems Biology
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Mouse CD115 ELISA Kit - orb219606 from Biorbyt
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Human CD115 ELISA Kit - abx056055 from Abbexa
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Colony Stimulating Factor 1 Receptor (CSF1R/M-CSFR), Human, ELISA Kit - PB-0807 from ARP American Research Products
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Macrophage colony-stimulating factor 1 receptor, CSF1R, Human, ELISA Kit - E1594h from ARP American Research Products
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Macrophage Colony-Stimulating Factor Receptor, M-CSFR, Human, ELISA Kit - CSB-E10012h from ARP American Research Products
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Macrophage Colony-Stimulating Factor Receptor, M-CSFR/CD115, Human, ELISA Kit - YHB1936Hu from ARP American Research Products
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