CSF1R

Gene Symbol	CSF1R
Entrez Gene	1436
Alt Symbol	C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
Species	Human
Gene Type	protein-coding
Description	colony stimulating factor 1 receptor
Other Description	CD115 antigen\|CSF-1 receptor\|FMS proto-oncogene\|McDonough feline sarcoma viral (v-fms) oncogene homolog\|macrophage colony stimulating factor I receptor\|macrophage colony-stimulating factor 1 receptor\|proto-oncogene c-Fms
Swissprots	D3DQG2 P07333 Q6LDY4 B5A955 Q86VW7 Q6LDW5
Accessions	AAA35848 AAA35849 AAA88039 AAB51235 AAB51696 CAJ32237 CAV32774 CBX55881 CCA65436 EAW61749 EAW61750 P07333 AB208819 BAD92056 AI863331 AK294467 BAG57697 AK304491 BAG65300 BC047521 AAH47521 BC129939 AAI29940 BM562096 BM825705 BQ028933 BX648599 CD620053 DA219251 DR001419 EU826593 ACF47629 M14193 AAA35834 M25786 AAA58421 X03663 CAA27300 NM_001288705 NP_001275634 NM_005211 NP_005202 NR_109969
Function	Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed in bone marrow and in differentiated blood mononuclear cells.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Endocytosis, Osteoclast differentiation, PI3K-Akt signaling pathway

Phospho-M-CSF Receptor (Tyr923) Antibody - 3406 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from FDCP1/fms cells, untreated or M-CSF treated, using Phospho-M-CSF Receptor (Tyr923) Antibody (upper) or M-CSF Receptor Antibody #3152 (lower).

Phospho-M-CSF Receptor (Tyr546) Antibody - 3083 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of Bac1.2F5 cells, untreated or stimulated with CSF-1, using Phospho-M-CSF Receptor (Tyr546) Antibody (upper) or M-CSF Receptor Antibody #3152 (lower).

Phospho-M-CSF Receptor (Tyr723) Antibody - 3151 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from GDM-1 cells, untreated or λ phosphatase-treated, using Phospho-M-CSF Receptor (Tyr723) Antibody (upper) or M-CSF Receptor Antibody #3152 (lower).

Phospho-M-CSF Receptor (Tyr699) Antibody - 3399 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from FDCP1/fms cells, untreated or M-CSF treated, using Phospho-M-CSF Receptor (Tyr699) Antibody (upper) or M-CSF Receptor Antibody #3152 (lower).

Phospho-M-CSF Receptor (Tyr699) (D10B11) Rabbit mAb - 12251 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D10B11

Western blot analysis of extracts from GDM1 cells, serum-starved overnight and untreated (-) or treated with Human Macrophage Colony Stimulating Factor (hM-CSF) #8929 (100 ng/ml, 10 min; +), using Phospho-M-CSF Receptor (Tyr699) (D10B11) Rabbit mAb (upper) or M-CSF Receptor Antibody #3152 (lower).

Phospho-M-CSF Receptor (Tyr708) Antibody - 3080 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from Bac1.2F5 cells, untreated or stimulated with M-CSF, using Phospho-M-CSF Receptor (Tyr708) Antibody (upper) or M-CSF Receptor Antibody #3152 (lower).

Phospho-M-CSF Receptor (Tyr708) (D5F4Y) Rabbit mAb - 14591 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D5F4Y

Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb - 3155 from Cell Signaling Technology

Prices	$307.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	49C10

Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb specifically binds to phosphorylated M-CSF receptors, but not other phosphorylated protein tyrosine kinases. Western blot anlysis of extracts from various cell lines expressing different activated protein tyrosine kinases, using Phospho-M-CSF Receptor (Tyr723) (49C10) Rabbit mAb (upper). The same membrane was stripped and reprobed with Phospho-Tyrosine Monoclonal Antibody (P-Tyr-100) (lower).

Phospho-M-CSF Receptor (Tyr809) Antibody - 3154 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from Bac1.2F5 and FDCP1/fms cells overexpressing mouse M-CSF receptors, untreated or M-CSF-stimulated (40 ng/ml for 1 minute), using Phospho-M-CSF Receptor (Tyr809) Antibody.

M-CSF Receptor Antibody - 3152 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from GDM-1 cells, untreated or λ phosphatase-treated, using Phospho-M-CSF Receptor (Tyr723) Antibody #3151 (upper) or M-CSF Receptor Antibody (lower).

M-CSF Receptor (E7S2S) Rabbit mAb - 14582 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	E7S2S

Western blot analysis of extracts from GDM-1 and NKM-1 cells using M-CSF Receptor (E7S2S) Rabbit mAb.

c-Fms/CSF-1R (B-8) - sc-46662 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

c-Fms/CSF-1R (B-8): sc-46662. Western blot analysis of c-Fms/CSF-1R expression in THP-1 (A) and HL-60 (B) whole cell lysates.

c-Fms/CSF-1R (D-8) - sc-365719 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

c-Fms/CSF-1R (D-8): sc-365719. Western blot analysis of c-Fms/CSF-1R expression in non-transfected: sc-117752 (A) and mouse c-Fms/CSF-1R transfected: sc-118887 (B) 293T whole cell lysates.

c-Fms/CSF-1R (3-4A4) - sc-02 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rat
Clonality	Monoclonal

c-Fms/CSF-1R (3-4A4) PE. Intracellular FCM analysis of fixed and permeabilized RAW 264.7 cells. Black line histogram represents the isotype control, normal rat IgG<sub>2b</sub>: sc-2873.

c-Fms/CSF-1R (G-17) - sc-31638 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

c-Fms/CSF-1R (C-20) - sc-692 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

c-Fms/CSF-1R (C-20): sc-692. Western blot analysis of CSF-1R expression in RAW 264.7 whole cell lysate. The two major bands represent differentially glycosylated receptors.

c-Fms/CSF-1R (2-4A5) - sc-01 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rat
Clonality	Monoclonal

Western blot analysis of human recombinant c-Fms/CSF-1R immunopreciptated with c-Fms/CSF-1R (2-4A5): sc-01 and detected with c-Fms/CSF-1R (H-300): sc-13949.

c-Fms/CSF-1R (3-4A4-E4) - sc-57047 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rat
Clonality	Monoclonal

c-Fms/CSF-1R (H-300) - sc-13949 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

c-Fms/CSF-1R (H-300): sc-13949. Western blot analysis of c-Fms/CSF-1R expression in RAW 264.7 whole cell lysate. The two major bands represent differentially glycosylated receptors.

c-Fms/CSF-1R (5J15) - sc-70452 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rat
Clonality	Monoclonal

c-Fms/CSF-1R (0.N.179) - sc-70453 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rat
Clonality	Monoclonal

c-Fms/CSF-1R (0.N.178) - sc-70451 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rat
Clonality	Monoclonal

p-c-Fms/CSF-1R (Tyr 723) - sc-33357 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

p-c-Fms/CSF-1R (Tyr 708) - sc-33358 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-MCSF Receptor (phospho Y561) antibody - ab192810 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MCSF Receptor (phospho Y561) antibody (ab192810) at 1/500 dilutionLane 1 : HepG2 cell extracts treated with PMALane 2 : HepG2 cell extracts treated with PMA with antigen specific peptide

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