| Gene Symbol |
CSF1R
|
| Entrez Gene |
1436
|
| Alt Symbol |
C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
colony stimulating factor 1 receptor
|
| Other Description |
CD115 antigen|CSF-1 receptor|FMS proto-oncogene|McDonough feline sarcoma viral (v-fms) oncogene homolog|macrophage colony stimulating factor I receptor|macrophage colony-stimulating factor 1 receptor|proto-oncogene c-Fms
|
| Swissprots |
D3DQG2 P07333 Q6LDY4 B5A955 Q86VW7 Q6LDW5
|
| Accessions |
AAA35848 AAA35849 AAA88039 AAB51235 AAB51696 CAJ32237 CAV32774 CBX55881 CCA65436 EAW61749 EAW61750 P07333 AB208819 BAD92056 AI863331 AK294467 BAG57697 AK304491 BAG65300 BC047521 AAH47521 BC129939 AAI29940 BM562096 BM825705 BQ028933 BX648599 CD620053 DA219251 DR001419 EU826593 ACF47629 M14193 AAA35834 M25786 AAA58421 X03663 CAA27300 NM_001288705 NP_001275634 NM_005211 NP_005202 NR_109969
|
| Function |
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in bone marrow and in differentiated blood mononuclear cells.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Endocytosis, Osteoclast differentiation, PI3K-Akt signaling pathway
|
![Western Blot: MCSF Receptor Overexpression Lysate (Adult Normal) [NBL1-09514] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MCSF Receptor.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6237_MCSF%2520Receptor%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09514-img0002.jpg)