PPARG

Gene Symbol	PPARG
Entrez Gene	5468
Alt Symbol	CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
Species	Human
Gene Type	protein-coding
Description	peroxisome proliferator-activated receptor gamma
Other Description	PPAR-gamma|nuclear receptor subfamily 1 group C member 3|peroxisome proliferator-activated nuclear receptor gamma variant 1
Swissprots	Q15180 B5BUA1 O14515 O00684 Q15179 O00710 Q96J12 Q86U60 P37231 A8K3G6 Q15832 Q0QJH8 Q15178
Accessions	AAK17925 AAN38992 BAA23353 BAA23354 CBX54350 EAW64123 EAW64124 EAW64125 P37231 AB097931 BAD20647 AB107271 BAD34540 AB307692 BAH02283 AB451337 BAG70151 AB451486 BAG70300 AB472042 BAI63629 AB565476 BAM71699 AJ563369 CAD91388 AJ563370 CAD91389 AJ698135 CAG29019 AK223528 BAD97248 AK290581 BAF83270 AL523434 BC006811 AAH06811 BG323933 BI820841 BM923992 BQ925271 BT007281 AAP35945 D83233 BAA18949 DQ356894 ABC97372 DQ891108 ABM82034 DQ894289 ABM85215 HQ692866 ADZ17377 U63415 AAB04028 U79012 AAC51248 X90563 CAA62152 XM_011533840 XP_011532142 XM_011533841 XP_011532143 XM_011533842 XP_011532144 XM_011533843 XP_011532145 XM_011533844 XP_011532146 NM_005037 NP_005028 NM_015869 NP_056953 NM_138711 NP_619725 NM_138712 NP_619726
Function	Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). {ECO:0000250|UniProtKB:P37238, ECO:0000269|PubMed:16150867, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:9065481}.
Subcellular Location	Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation.
Tissue Specificity	Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. {ECO:0000269|PubMed:9065481}.
Top Pathways	Huntington's disease, PPAR signaling pathway, Thyroid cancer, Osteoclast differentiation, AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PPAR gamma Transcription Factor Assay Kit - ab133101 from Abcam Category Cellular Assay Prices $494.00 Sizes 96 tests

Rat PPARG / PPAR Gamma ELISA Kit (Sandwich ELISA) - LS-F4266 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human PPARG / PPAR Gamma ELISA Kit (Sandwich ELISA) - LS-F4265 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse PPARG / PPAR Gamma ELISA Kit (Sandwich ELISA) - LS-F4267 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat PPARG / PPAR Gamma ELISA Kit (DNA-Binding ELISA) - LS-F792 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-PPARG / PPAR Gamma (Ser112) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1212 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat PPARG / PPAR Gamma ELISA Kit (Cell-Based ELISA) - LS-F2267 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Bovine PPARG / PPAR Gamma ELISA Kit (Sandwich ELISA) - LS-F7730 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.133 ng/ml Range 0.156-10 ng/ml

Rabbit PPARG / PPAR Gamma ELISA Kit (Sandwich ELISA) - LS-F9286 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.78 ng/ml Range 0.156-10 ng/ml

Human PPARG / PPAR Gamma ELISA Kit (Sandwich ELISA) - LS-F12376 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

PPAR gamma/NR1C3 Colorimetric Assay Kit - KA1358 from Novus Biologicals Category Assay Kit Prices $659.00 Sizes 1 kit

Human PPARg ELISA Kit - abx152807 from Abbexa Category ELISA Kit Sensitivity 0.29 ng/ml Range 0.781 ng/ml - 50 ng/ml

Peroxisome Proliferator Activated Receptor Gamma (PPARg), Human, ELISA Kit - SEA886Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.051ng/mL Range 0.156-10ng/mL

Peroxisome Proliferator-activated receptor _, PPAR-_, Human, ELISA Kit - CSB-E08623h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 19.53 pg/ml Range 78.13 pg/ml -5000 pg/ml

Peroxisome proliferator-activated receptor gamma, PPARG, Human, ELISA Kit - E0886h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Peroxisome Proliferator Activated Receptor Gamma, PPAR-y, Human, ELISA Kit - E-EL-H1361 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Peroxisome Proliferator-activated receptor y, PPAR-y, Mouse, ELISA Kit - E-EL-M0893 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Peroxisome Proliferator-Activated Receptor y, PPAR-y, Rat, ELISA Kit - E-EL-R0724 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Peroxisome Proliferator Activated Receptor Gamma, PPAR-y, Rabbit, ELISA Kit - E-EL-RB1265 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Peroxisome Proliferator Activated Receptor Gamma, PPAR-y, Chicken, ELISA Kit - E-EL-Ch0246 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Peroxisome Proliferator Activated Receptor Gamma, PPAR-y, Porcine, ELISA Kit - E-EL-P2214 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Peroxisome Proliferator Activated Receptor Gamma, PPAR-y, Sheep, ELISA Kit - E-EL-S0927 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Peroxisome Proliferator Activated Receptor Gamma, PPAR-y, Guinea Pig, ELISA Kit - E-EL-GP0306 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Peroxisome Proliferator Activated Receptor Gamma, PPAR-y, Monkey, ELISA Kit - E-EL-MK0507 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

PPARG Transcription Factor Assay Kit - KA1358 from Acris Antibodies Category ELISA Kit Prices $560.00 Sizes 1 kit

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