PPARG

Gene Symbol PPARG
Entrez Gene 5468
Alt Symbol CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
Species Human
Gene Type protein-coding
Description peroxisome proliferator-activated receptor gamma
Other Description PPAR-gamma|nuclear receptor subfamily 1 group C member 3|peroxisome proliferator-activated nuclear receptor gamma variant 1
Swissprots Q15180 B5BUA1 O14515 O00684 Q15179 O00710 Q96J12 Q86U60 P37231 A8K3G6 Q15832 Q0QJH8 Q15178
Accessions AAK17925 AAN38992 BAA23353 BAA23354 CBX54350 EAW64123 EAW64124 EAW64125 P37231 AB097931 BAD20647 AB107271 BAD34540 AB307692 BAH02283 AB451337 BAG70151 AB451486 BAG70300 AB472042 BAI63629 AB565476 BAM71699 AJ563369 CAD91388 AJ563370 CAD91389 AJ698135 CAG29019 AK223528 BAD97248 AK290581 BAF83270 AL523434 BC006811 AAH06811 BG323933 BI820841 BM923992 BQ925271 BT007281 AAP35945 D83233 BAA18949 DQ356894 ABC97372 DQ891108 ABM82034 DQ894289 ABM85215 HQ692866 ADZ17377 U63415 AAB04028 U79012 AAC51248 X90563 CAA62152 XM_011533840 XP_011532142 XM_011533841 XP_011532143 XM_011533842 XP_011532144 XM_011533843 XP_011532145 XM_011533844 XP_011532146 NM_005037 NP_005028 NM_015869 NP_056953 NM_138711 NP_619725 NM_138712 NP_619726
Function Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). {ECO:0000250|UniProtKB:P37238, ECO:0000269|PubMed:16150867, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:9065481}.
Subcellular Location Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation.
Tissue Specificity Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. {ECO:0000269|PubMed:9065481}.
Top Pathways Huntington's disease, PPAR signaling pathway, Thyroid cancer, Osteoclast differentiation, AMPK signaling pathway

PPARγ (C26H12) Rabbit mAb - 2435 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C26H12
Western blot analysis of extracts from NIH/3T3 and 3T3-L1 cells (differentiated 6 days) using PPARγ (C26H12) Rabbit mAb.

PPARγ (81B8) Rabbit mAb - 2443 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 81B8
Western blot analysis of extracts from NIH/3T3 and 3T3-L1 cells (differentiated 6 days) using PPARγ (81B8) Rabbit mAb.

PPARγ (D69) Antibody - 2430 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH/3T3 and NIH/3T3-L1 cells (differentiated 6 days) using PPARγ (D69) Antibody.

PPARgamma Antibody - 2492 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

PPARγ (B-5) - sc-271392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PPARγ (B-5): sc-271392. Western blot analysis of PPARγ expression in non-transfected: sc-117752 (A) and human PPARγ transfected: sc-110516 (B) 293T whole cell lysates.

PPARγ2 (E-9) - sc-390740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PPARγ2 (E-9): sc-390740. Western blot analysis of PPARγ2 expression in non-transfected: sc-117752 (A) and mouse PPARγ transfected: sc-122729 (B) whole cell lysates.

PPARγ (C-20) - sc-1981 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PPARγ (C-20): sc-1981. Western blot analysis of PPARγ expression in HEK293 (A) and Jurkat (B) whole cell lysates.

PPARγ (E-8) - sc-7273 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PPARγ (E-8): sc-7273. Immunofluorescence staining of methanol-fixed Jurkat cells (A) and immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue (B) showing nuclear localization.

PPARγ (H-100) - sc-7196 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PPARγ (H-100): sc-7196. Western blot analysis of PPARγ expression in non-transfected: sc-110760 (A) and human PPARγ transfected: sc-110516 (B) 293 whole cell lysates.

PPARγ (8D1H8H4) - sc-81152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

PPARγ (I-18) - sc-6285 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PPARγ (I-18): sc-6285. Immunofluorescence staining of methanol-fixed U-937 cells showing nuclear localization.

PPARγ (K-18) - sc-6284 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PPARγ (K-18): sc-6284. Western blot analysis of PPARγ expression in non-transfected: sc-117752 (A) and mouse PPARγ transfected: sc-122729 (B) 293T whole cell lysates.

PPARγ (N-20) - sc-1984 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PPARγ (N-20): sc-1984. Western blot analysis of human recombinant PPARγ fusion protein.

PPARγ 2 (A-1) - sc-166731 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PPARγ<sub>2</sub> (A-1): sc-166731. Western blot analysis of PPARγ expression in non-transfected: sc-117752 (A) and mouse PPARγ transfected: sc-122729 (B) 293T whole cell lysates.

PPARγ2 (G-18) - sc-22020 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PPARγ2 (G-18): sc-22020. Western blot analysis of PPARγ expression in non-transfected: sc-117752 (A) and mouse PPARγ transfected: sc-122729 (B) 293T whole cell lysates.

PPARγ2 (N-19) - sc-22022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PPARγ2 (N-19): sc-22022. Western blot analysis of PPARγ2 expression in U-937 whole cell lysate.

Anti-PPAR gamma [EP4394(N)] antibody - ab191407 from Abcam

Prices $99.00, $376.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP4394(N)
All lanes : Anti-PPAR gamma [EP4394(N)] antibody (ab191407) at 1/1000 dilutionLane 1 : 3T3-L1 cell lysateLane 2 : K562 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-PPAR gamma (phospho S112) antibody - ab195925 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PPAR gamma (phospho S112) antibody (ab195925) at 1/500 dilutionLane 1 : Paclitaxel treated Jurkat whole cell lysate with antigen-specific peptideLane 2 : Paclitaxel treated Jurkat whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-PPAR gamma antibody [3A4A9,1E6A1] - ab70405 from Abcam

Host Mouse
Clonality Monoclonal
Clone 3A4A9,1E6A1
All lanes : Anti-PPAR gamma antibody [3A4A9,1E6A1] (ab70405) at 1/500 dilutionLane 1 : Molecular weight markerLane 2 : Truncated PPAR gamma-His recombinant proteinLane 3 : Full length PPAR gamma transfected CHO-K1 cell lysate

Anti-PPAR gamma antibody [8D1H8F4] - ab138004 from Abcam

Prices $378.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 8D1H8F4
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labelling PPAR gamma with ab138004 at 10 &microg/ml.

Anti-PPAR gamma 1+2 antibody [A3409A] - ChIP Grade - ab41928 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone A3409A
ab41928 staining PPAR gamma 1+2 in rat adiposoe cells (10 ug/mL) by immunohistochemistry, formalin-fixed paraffin embedded sections.

Anti-PPAR gamma antibody - ab19481 from Abcam

Prices $390.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
ab19481 staining PPARγ in U-87 MG cells treated with ciglitazone (ab141139), by ICC/IF. Increase of PPARγ cytoplasmic expression correlates with increased concentration of ciglitazone, as described in literature.The cells were incubated at 37°C for 24 hours in media containing different concentrations of ab141139 (ciglitazone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab19481 (5 μg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Anti-PPAR gamma antibody - ab27649 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-PPAR gamma antibody (ab27649) at 1 µg/ml + Mouse Brown Adipose Tissue Lysate at 20 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-PPAR gamma antibody - ab59256 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab59256, at 1/50 dilution, staining PPAR gamma in paraffin embedded human placenta tissue by Immunohistochemistry in the absence or presence of the immunising peptide.

Anti-PPAR gamma antibody - ab66343 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Mouse cornea and eyelid. Primary Antibody Dilution : 1:100. Secondary Antibody : Goat anti-rabbit-AlexaFluor-546. Secondary Antibody Dilution : 1:1000. Color/Signal Descriptions : PPARG: Green DAPI: Red. Gene Name : Ppar Gamma.
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