PPARG

Gene Symbol	PPARG
Entrez Gene	5468
Alt Symbol	CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
Species	Human
Gene Type	protein-coding
Description	peroxisome proliferator-activated receptor gamma
Other Description	PPAR-gamma|nuclear receptor subfamily 1 group C member 3|peroxisome proliferator-activated nuclear receptor gamma variant 1
Swissprots	Q15180 B5BUA1 O14515 O00684 Q15179 O00710 Q96J12 Q86U60 P37231 A8K3G6 Q15832 Q0QJH8 Q15178
Accessions	AAK17925 AAN38992 BAA23353 BAA23354 CBX54350 EAW64123 EAW64124 EAW64125 P37231 AB097931 BAD20647 AB107271 BAD34540 AB307692 BAH02283 AB451337 BAG70151 AB451486 BAG70300 AB472042 BAI63629 AB565476 BAM71699 AJ563369 CAD91388 AJ563370 CAD91389 AJ698135 CAG29019 AK223528 BAD97248 AK290581 BAF83270 AL523434 BC006811 AAH06811 BG323933 BI820841 BM923992 BQ925271 BT007281 AAP35945 D83233 BAA18949 DQ356894 ABC97372 DQ891108 ABM82034 DQ894289 ABM85215 HQ692866 ADZ17377 U63415 AAB04028 U79012 AAC51248 X90563 CAA62152 XM_011533840 XP_011532142 XM_011533841 XP_011532143 XM_011533842 XP_011532144 XM_011533843 XP_011532145 XM_011533844 XP_011532146 NM_005037 NP_005028 NM_015869 NP_056953 NM_138711 NP_619725 NM_138712 NP_619726
Function	Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). {ECO:0000250|UniProtKB:P37238, ECO:0000269|PubMed:16150867, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:9065481}.
Subcellular Location	Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation.
Tissue Specificity	Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. {ECO:0000269|PubMed:9065481}.
Top Pathways	Huntington's disease, PPAR signaling pathway, Thyroid cancer, Osteoclast differentiation, AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PPARG - MBS1274820 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC006811

Human PPARG cDNA clone(NM_138711.3) - CDFG008220 from Creative Biomart Species Human Accession NM_138711.3

Human PPARG cDNA clone(NM_138712.3) - CDFG008221 from Creative Biomart Species Human Accession NM_138712.3

Human PPARG cDNA clone(NM_005037.5) - CDFH014808 from Creative Biomart Species Human Accession NM_005037.5

Human PPARG cDNA clone(NM_015869.4) - CDFH014810 from Creative Biomart Species Human Accession NM_015869.4

Human PPARG ORF clone(NM_015869.4) - CDCL185779 from Creative Biomart Species Human Accession NM_015869.4

Human PPARG ORF Clone(NM_005037.5) - CDCR289482 from Creative Biomart Species Human Accession NM_005037.5

Human PPARG ORF Clone(NM_005037.5) - CDCR289483 from Creative Biomart Species Human Accession NM_005037.5

Human PPARG ORF Clone(NM_005037.5) - CDCR289484 from Creative Biomart Species Human Accession NM_005037.5

Human PPARG ORF Clone(NM_015869.4) - CDCR300046 from Creative Biomart Species Human Accession NM_015869.4

Human PPARG ORF Clone(NM_015869.4) - CDCR300047 from Creative Biomart Species Human Accession NM_015869.4

Human PPARG ORF Clone(NM_015869.4) - CDCR300048 from Creative Biomart Species Human Accession NM_015869.4

Human PPARG ORF Clone(NM_138711.3) - CDCR316804 from Creative Biomart Species Human Accession NM_138711.3

Human PPARG ORF Clone(NM_138711.3) - CDCR316805 from Creative Biomart Species Human Accession NM_138711.3

Human PPARG ORF Clone(NM_138712.3) - CDCR316806 from Creative Biomart Species Human Accession NM_138712.3

Human PPARG ORF Clone(NM_138712.3) - CDCR316807 from Creative Biomart Species Human Accession NM_138712.3

Human PPARG Gene ORF cDNA clone in cloning vector - HG12019-G from Sino Biological Species Human

Human PPARG Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12019-CF from Sino Biological Species Human

Human PPARG Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-tagged - HG12019-NM from Sino Biological Species Human Accession NM_015869.4

Human PPARG Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12019-CM from Sino Biological Species Human

Human PPARG Gene ORF cDNA clone expression plasmid, C-His tag - HG12019-CH from Sino Biological Species Human

Human PPARG Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12019-ACG from Sino Biological Species Human

Human PPARG Gene ORF cDNA clone expression plasmid - HG12019-UT from Sino Biological Species Human

Human PPARG Gene ORF cDNA clone expression plasmid, C-HA tag - HG12019-CY from Sino Biological Species Human

Human PPARG Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG12019-G-N from Sino Biological Species Human Accession NM_015869.4

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