DEAF1

Gene Symbol	DEAF1
Entrez Gene	10522
Alt Symbol	MRD24, NUDR, SPN, ZMYND5
Species	Human
Gene Type	protein-coding
Description	DEAF1 transcription factor
Other Description	deformed epidermal autoregulatory factor 1 homolog|nuclear DEAF-1-related transcriptional regulator|suppressin|zinc finger MYND domain-containing protein 5
Swissprots	A8K1F8 C7T5V5 O75398 O75399 O15152 O75512 O75513 O75511 O75510 Q9UET1 A8K5R8
Accessions	EAX02370 EAX02371 O75398 AB209831 BAD93068 AF007165 AAB62704 AF049459 AAC79676 AF049460 AAC79677 AF068892 AAC25714 AF068893 AAC25715 AF068894 AAC25716 AF068895 AAC25717 AF068896 AAC25718 AF068897 AAC25719 AK289873 BAF82562 AK291383 BAF84072 BC042135 BC053322 AAH53322 BI463261 BM696110 BQ267366 EU831436 ACE87123 EU831528 ACE86447 FJ985253 ACU88060 HY094363 HY324291 XM_011519842 XP_011518144 XM_011519843 XP_011518145 XR_428838 XR_930843 NM_001293634 NP_001280563 NM_021008 NP_066288
Function	Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'- AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein- protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. {ECO:0000269|PubMed:10521432, ECO:0000269|PubMed:11427895, ECO:00
Subcellular Location	Isoform 3: Secreted. Note=Secreted in some cell types.
Tissue Specificity	Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls. Highly expressed in fetal and adult brain. {ECO:0000269|PubMed:19668219, ECO:0000269|PubMed:24726472}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Suppressin (A-7) - sc-376477 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Suppressin (C-8) - sc-398387 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Suppressin (E-5) - sc-514180 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Suppressin (K-18) - sc-69012 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Suppressin (N-16) - sc-69014 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Suppressin (L-17) - sc-69013 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Deformed Epidermal Autoregulatory Factor 1 antibody - ab172391 from Abcam Prices $370.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-Deformed Epidermal Autoregulatory Factor 1 antibody - ab151415 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Deformed Epidermal Autoregulatory Factor 1 antibody [EPR10322] - ab156591 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR10322

Anti-Deformed Epidermal Autoregulatory Factor 1 antibody - ab75792 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Deformed Epidermal Autoregulatory Factor 1 antibody - ab50719 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Deformed Epidermal Autoregulatory Factor 1 antibody - ab56668 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-Deformed Epidermal Autoregulatory Factor 1 antibody - C-terminal - ab75722 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NUDR / DEAF1 Antibody - LS-C64642 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-NUDR / DEAF1 Antibody (C-Terminus) - LS-C30231 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NUDR / DEAF1 Antibody (aa38-87) - LS-C80262 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NUDR / DEAF1 Antibody (clone 349C4a) - LS-C184584 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 349C4a

Anti-NUDR / DEAF1 Antibody (clone 3E6) - LS-C139420 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3E6

Anti-NUDR / DEAF1 Antibody (aa474-502, Biotin) - LS-C255996 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUDR / DEAF1 Antibody (aa474-502, APC) - LS-C255995 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUDR / DEAF1 Antibody (aa474-502, AP) - LS-C255994 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUDR / DEAF1 Antibody (aa474-502, FITC) - LS-C255997 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUDR / DEAF1 Antibody (aa368-400) - LS-C98565 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NUDR / DEAF1 Antibody (aa474-502, Azide-free, HRP) - LS-C255998 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUDR / DEAF1 Antibody (aa474-502, PE) - LS-C256000 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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