DEAF1

Gene Symbol	DEAF1
Entrez Gene	10522
Alt Symbol	MRD24, NUDR, SPN, ZMYND5
Species	Human
Gene Type	protein-coding
Description	DEAF1 transcription factor
Other Description	deformed epidermal autoregulatory factor 1 homolog|nuclear DEAF-1-related transcriptional regulator|suppressin|zinc finger MYND domain-containing protein 5
Swissprots	A8K1F8 C7T5V5 O75398 O75399 O15152 O75512 O75513 O75511 O75510 Q9UET1 A8K5R8
Accessions	EAX02370 EAX02371 O75398 AB209831 BAD93068 AF007165 AAB62704 AF049459 AAC79676 AF049460 AAC79677 AF068892 AAC25714 AF068893 AAC25715 AF068894 AAC25716 AF068895 AAC25717 AF068896 AAC25718 AF068897 AAC25719 AK289873 BAF82562 AK291383 BAF84072 BC042135 BC053322 AAH53322 BI463261 BM696110 BQ267366 EU831436 ACE87123 EU831528 ACE86447 FJ985253 ACU88060 HY094363 HY324291 XM_011519842 XP_011518144 XM_011519843 XP_011518145 XR_428838 XR_930843 NM_001293634 NP_001280563 NM_021008 NP_066288
Function	Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'- AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein- protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. {ECO:0000269|PubMed:10521432, ECO:0000269|PubMed:11427895, ECO:00
Subcellular Location	Isoform 3: Secreted. Note=Secreted in some cell types.
Tissue Specificity	Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls. Highly expressed in fetal and adult brain. {ECO:0000269|PubMed:19668219, ECO:0000269|PubMed:24726472}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Suppressin CRISPR/Cas9 KO Plasmid (h) - sc-409787 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Suppressin HDR Plasmid (h) - sc-409787-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Suppressin Double Nickase Plasmid (h) - sc-409787-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Suppressin Double Nickase Plasmid (h2) - sc-409787-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Suppressin CRISPR Activation Plasmid (h) - sc-409787-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Suppressin CRISPR Activation Plasmid (h2) - sc-409787-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Suppressin Lentiviral Activation Particles (h) - sc-409787-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Suppressin Lentiviral Activation Particles (h2) - sc-409787-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Suppressin siRNA (h) - sc-76613 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Suppressin shRNA Plasmid (h) - sc-76613-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Suppressin shRNA (h) Lentiviral Particles - sc-76613-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU074861 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7075 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7075 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02727 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02727

DEAF1 siRNA (Human) - CRH7149 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DEAF1 RNAi - H00010522-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

DEAF1 - MBS8237186 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human DEAF1 (NM_021008.2) - SHH276229 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human DEAF1(NM_021008.2) - SHG227593 from Creative biogene Category siRNA Species Reactivities Human

DEAF1 shRNA Plasmid (Human) - CHH7149 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

DEAF1 miRNA 3'UTR clone - MiUTR1H-02746 from Creative biogene Species Reactivities Human

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