| Gene Symbol |
SNX27
|
| Entrez Gene |
81609
|
| Alt Symbol |
MRT1, MY014
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sorting nexin family member 27
|
| Other Description |
methamphetamine-responsive transcript 1|sorting nexin-27
|
| Swissprots |
Q86UB1 Q4AEJ5 Q5VWB2 Q5VWB0 Q5VWB1 Q96D79 Q32Q36 Q96L92 Q9H3K8 Q6IPP6
|
| Accessions |
EAW53423 EAW53424 EAW53425 EAW53426 EAW53427 EAW53428 Q96L92 AB007957 BAE16986 AF060509 AAG43127 AJ009640 AK001395 AY044866 AAK97797 BC012184 AAH12184 BC051817 AAH51817 BC071825 AAH71825 BC100998 AAI00999 BC100999 AAI01000 BC101000 AAI01001 BC101822 AAI01823 BC101824 AAI01825 BC107862 AAI07863 BG472531 BM560557 BU676479 CB853160 JF432459 ADZ15676 XM_005245509 XP_005245566 XM_005245510 XP_005245567 XM_005245511 XP_005245568 XM_011510024 XP_011508326 XM_011510025 XP_011508327 XM_011510026 XP_011508328 NM_030918 NP_112180
|
| Function |
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ- binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. {ECO:0000269|PubMed:17351151, ECO:0000269|PubMed:20733053, ECO:0000269|PubMed:21300787, ECO:0000269|PubMed:
|
| Subcellular Location |
Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.
|
| Tissue Specificity |
Widely expressed. Expressed in cells of hematopoietic origin (at protein level). {ECO:0000269|PubMed:17351151, ECO:0000269|PubMed:17577583, ECO:0000269|PubMed:21300787}.
|