SNX27

Gene Symbol SNX27
Entrez Gene 81609
Alt Symbol MRT1, MY014
Species Human
Gene Type protein-coding
Description sorting nexin family member 27
Other Description methamphetamine-responsive transcript 1|sorting nexin-27
Swissprots Q86UB1 Q4AEJ5 Q5VWB2 Q5VWB0 Q5VWB1 Q96D79 Q32Q36 Q96L92 Q9H3K8 Q6IPP6
Accessions EAW53423 EAW53424 EAW53425 EAW53426 EAW53427 EAW53428 Q96L92 AB007957 BAE16986 AF060509 AAG43127 AJ009640 AK001395 AY044866 AAK97797 BC012184 AAH12184 BC051817 AAH51817 BC071825 AAH71825 BC100998 AAI00999 BC100999 AAI01000 BC101000 AAI01001 BC101822 AAI01823 BC101824 AAI01825 BC107862 AAI07863 BG472531 BM560557 BU676479 CB853160 JF432459 ADZ15676 XM_005245509 XP_005245566 XM_005245510 XP_005245567 XM_005245511 XP_005245568 XM_011510024 XP_011508326 XM_011510025 XP_011508327 XM_011510026 XP_011508328 NM_030918 NP_112180
Function Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ- binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. {ECO:0000269|PubMed:17351151, ECO:0000269|PubMed:20733053, ECO:0000269|PubMed:21300787, ECO:0000269|PubMed:
Subcellular Location Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.
Tissue Specificity Widely expressed. Expressed in cells of hematopoietic origin (at protein level). {ECO:0000269|PubMed:17351151, ECO:0000269|PubMed:17577583, ECO:0000269|PubMed:21300787}.

Human SNX27 full length protein - ab164350 from Abcam

Category Protein
Source Wheat germ
Species Human
ab164350 on a 12.5% SDS-PAGE stained with Coomassie Blue.

SNX27 Antibody Blocking Peptide - LS-E23809 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

SNX27 Antibody Blocking Peptide - LS-E10407 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

SNX27 Blocking Peptide - NBP1-45283PEP from Novus Biologicals

Category Peptide
Prices $69.00
Sizes 50 µg
Species Human

SNX27 Blocking Peptide - NBP1-45282PEP from Novus Biologicals

Category Peptide
Prices $69.00
Sizes 50 µg
Species Human

Recombinant Human SNX27 Protein - H00081609-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

SNX27-Antibody-Center-Blocking-Peptide - BP9947c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Sorting nexin-27 (SNX27) - H00081609-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Sorting nexin-27 (SNX27) - H00081609-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

SNX27 fusion protein - ag9447 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

SNX27 fusion protein - ag9466 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

Recombinant Human Sorting nexin-27(SNX27) - CSB-YP842704HU CSB-EP842704HU CSB-BP842704HU CSB-MP842704HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Sorting nexin-27 (SNX27) - TP318477 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
Sorting nexin-27 (SNX27)

SNX27 Protein - NBP2-13360PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

SNX27 Peptide, Human - M34GP14858H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Sorting nexin-27 (SNX27), Recombinant Protein - MBS1348136 from MyBioSource

Category Protein
Prices $1,335.00, $1,335.00, $1,555.00, $1,555.00, $2,210.00, $2,210.00, $2,670.00, $2,670.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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