SNX27

Gene Symbol	SNX27
Entrez Gene	81609
Alt Symbol	MRT1, MY014
Species	Human
Gene Type	protein-coding
Description	sorting nexin family member 27
Other Description	methamphetamine-responsive transcript 1|sorting nexin-27
Swissprots	Q86UB1 Q4AEJ5 Q5VWB2 Q5VWB0 Q5VWB1 Q96D79 Q32Q36 Q96L92 Q9H3K8 Q6IPP6
Accessions	EAW53423 EAW53424 EAW53425 EAW53426 EAW53427 EAW53428 Q96L92 AB007957 BAE16986 AF060509 AAG43127 AJ009640 AK001395 AY044866 AAK97797 BC012184 AAH12184 BC051817 AAH51817 BC071825 AAH71825 BC100998 AAI00999 BC100999 AAI01000 BC101000 AAI01001 BC101822 AAI01823 BC101824 AAI01825 BC107862 AAI07863 BG472531 BM560557 BU676479 CB853160 JF432459 ADZ15676 XM_005245509 XP_005245566 XM_005245510 XP_005245567 XM_005245511 XP_005245568 XM_011510024 XP_011508326 XM_011510025 XP_011508327 XM_011510026 XP_011508328 NM_030918 NP_112180
Function	Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ- binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. {ECO:0000269|PubMed:17351151, ECO:0000269|PubMed:20733053, ECO:0000269|PubMed:21300787, ECO:0000269|PubMed:
Subcellular Location	Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.
Tissue Specificity	Widely expressed. Expressed in cells of hematopoietic origin (at protein level). {ECO:0000269|PubMed:17351151, ECO:0000269|PubMed:17577583, ECO:0000269|PubMed:21300787}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SNX27 (1C6) - sc-130564 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SNX27 (H-201) - sc-366387 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SNX27 (K-14) - sc-162250 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SNX27 (Y-14) - sc-162251 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SNX27 antibody - ab103354 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 antibody [1C6] - ab77799 from Abcam Prices $398.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C6

Anti-SNX27 antibody [1C6] - BSA and Azide free - ab173233 from Abcam Prices $372.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C6

Anti-SNX27 Antibody (aa150-200, Biotin) - LS-C143359 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa150-200, DY650) - LS-C143360 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa150-200, DY488) - LS-C143361 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa150-200, HRP) - LS-C143362 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa150-200, DY550) - LS-C143363 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa450-500, Biotin) - LS-C143365 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa450-500, DY650) - LS-C143366 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa450-500, DY488) - LS-C143367 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa450-500, HRP) - LS-C143368 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa450-500, DY550) - LS-C143369 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa150-200) - LS-C143358 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa313-340, AP) - LS-C241078 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa313-340, APC) - LS-C241079 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa313-340, FITC) - LS-C241080 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa313-340, PE) - LS-C241081 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa319-349) - LS-C325257 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa313-340) - LS-C161371 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SNX27 Antibody (aa57-106) - LS-C186772 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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