| Gene Symbol |
UST
|
| Entrez Gene |
10090
|
| Alt Symbol |
2OST
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
uronyl-2-sulfotransferase
|
| Other Description |
dermatan/chondroitin sulfate 2-sulfotransferase|uronyl 2-sulfotransferase
|
| Swissprots |
B2RCX6 Q9Y2C2
|
| Accessions |
EAW47812 Q9Y2C2 AB020316 BAA77510 AI570697 AJ420554 AK292922 BAF85611 AK315320 BAG37723 BC093668 AAH93668 BC093694 AAH93694 CA842761 DB496757 XM_005266790 XP_005266847 XM_011535376 XP_011533678 XM_011535377 XP_011533679 XM_011535378 XP_011533680 XR_942249 NM_005715 NP_005706
|
| Function |
Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10187838}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|