Gene Symbol | UGGT1 |
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Entrez Gene | 56886 |
Alt Symbol | HUGT1, UGCGL1, UGT1 |
Species | Human |
Gene Type | protein-coding |
Description | UDP-glucose glycoprotein glucosyltransferase 1 |
Other Description | UDP--Glc:glycoprotein glucosyltransferase|UDP-glucose ceramide glucosyltransferase-like 1|UDP-glucose:glycoprotein glucosyltransferase 1 |
Swissprots | Q9H8I4 Q53SL3 Q8IW30 Q53QP2 Q9NYU2 |
Accessions | AAY14735 AAY14885 EAW95356 Q9NYU2 AF227905 AAF66232 AK023240 AK023671 BAB14632 AK074251 AK074376 AK293066 BAF85755 AK309101 BC041098 AAH41098 BC047727 BP356698 DB226703 XM_006712634 XP_006712697 XM_006712635 XP_006712698 XM_006712636 XP_006712699 XR_922969 NM_001025777 NM_020120 NP_064505 NR_027671 |
Function | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:10694380}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:10694380}. |
Tissue Specificity | Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart. {ECO:0000269|PubMed:10694380}. |
Top Pathways | Protein processing in endoplasmic reticulum |
UGGT1 / UGGT Antibody Blocking Peptide - LS-E2221 from LifeSpan Bioscience
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UGGT1 / UGGT Antibody Blocking Peptide - LS-E17855 from LifeSpan Bioscience
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UGCGL1-Antibody-C-term-Blocking-Peptide - BP13145b from Abgent, a WuXi AppTec company
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UGCGL1 Blocking Peptide - 33R-1061 from Fitzgerald
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UGCGL1 fusion protein - ag5369 from Proteintech Group
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UGCGL1 fusion protein - Ag5940 from Proteintech Group
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Recombinant UDP-Glucose Glycoprotein Glucosyltransferase 1 (UGGT1) - RPJ269Hu01 from Uscn Life Science Inc.
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Recombinant UDP-Glucose Glycoprotein Glucosyltransferase 1 (UGGT1) - RPJ269Hu01 from Cloud-clone
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Recombinant Human UDP-glucose:glycoprotein glucosyltransferase 1(UGGT1) ,partial - CSB-YP878928HU CSB-EP878928HU CSB-BP878928HU CSB-MP878928HU from Cusabio
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UDP-Glucose Glycoprotein Glucosyltransferase 1 Protein (Recombinant) - abx166707 from Abbexa
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UGCGL1 Protein - abx164989 from Abbexa
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UGGT1 Recombinant Protein Antigen - NBP1-81652PEP from Novus Biologicals
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UGGT1 Recombinant Protein Antigen - NBP1-81651PEP from Novus Biologicals
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UGGT1 Peptide, Human - M34GP17043H from Creative Peptides
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Recombinant UDP-Glucose Glycoprotein Glucosyltransferase 1 (UGGT1) - RPU52332 from Biomatik
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UGGT1 Recombinant Protein (OPCD07825) - OPCD07825 from Aviva Systems Biology
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Recombinant Human UGGT1 protein, His & T7-tagged - UGGT1-1651H from Creative Biomart
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