Gene Symbol | UGGT1 |
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Entrez Gene | 56886 |
Alt Symbol | HUGT1, UGCGL1, UGT1 |
Species | Human |
Gene Type | protein-coding |
Description | UDP-glucose glycoprotein glucosyltransferase 1 |
Other Description | UDP--Glc:glycoprotein glucosyltransferase|UDP-glucose ceramide glucosyltransferase-like 1|UDP-glucose:glycoprotein glucosyltransferase 1 |
Swissprots | Q9H8I4 Q53SL3 Q8IW30 Q53QP2 Q9NYU2 |
Accessions | AAY14735 AAY14885 EAW95356 Q9NYU2 AF227905 AAF66232 AK023240 AK023671 BAB14632 AK074251 AK074376 AK293066 BAF85755 AK309101 BC041098 AAH41098 BC047727 BP356698 DB226703 XM_006712634 XP_006712697 XM_006712635 XP_006712698 XM_006712636 XP_006712699 XR_922969 NM_001025777 NM_020120 NP_064505 NR_027671 |
Function | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:10694380}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:10694380}. |
Tissue Specificity | Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart. {ECO:0000269|PubMed:10694380}. |
Top Pathways | Protein processing in endoplasmic reticulum |
UGGT1 CRISPR/Cas9 KO Plasmid (h) - sc-404451 from Santa Cruz Biotechnology
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UGGT1 HDR Plasmid (h) - sc-404451-HDR from Santa Cruz Biotechnology
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UGGT1 Double Nickase Plasmid (h) - sc-404451-NIC from Santa Cruz Biotechnology
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UGGT1 Double Nickase Plasmid (h2) - sc-404451-NIC-2 from Santa Cruz Biotechnology
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UGGT1 CRISPR Activation Plasmid (h) - sc-404451-ACT from Santa Cruz Biotechnology
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UGGT1 CRISPR Activation Plasmid (h2) - sc-404451-ACT-2 from Santa Cruz Biotechnology
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UGGT1 Lentiviral Activation Particles (h) - sc-404451-LAC from Santa Cruz Biotechnology
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UGGT1 Lentiviral Activation Particles (h2) - sc-404451-LAC-2 from Santa Cruz Biotechnology
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UGGT1 siRNA (h) - sc-60098 from Santa Cruz Biotechnology
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UGGT1 shRNA Plasmid (h) - sc-60098-SH from Santa Cruz Biotechnology
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UGGT1 shRNA (h) Lentiviral Particles - sc-60098-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU032291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22453 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22453 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10070 from Sigma-Aldrich
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UGGT1 siRNA (Human) - CRJ1193 from Cohesion Biosciences
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UGGT1 - MBS8228561 from MyBioSource
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shRNA set against Human UGGT1 (NM_020120.3) - SHH440004 from Creative biogene
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Human UGGT1 siRNA - orb271694 from Biorbyt
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UGGT1 shRNA Plasmid (Human) - CHJ1193 from Cohesion Biosciences
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UGGT1 miRNA 3'UTR clone - MiUTR4H-TG09647 from Creative biogene
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