| Gene Symbol |
POLR3B
|
| Entrez Gene |
55703
|
| Alt Symbol |
C128, HLD8, INMAP, RPC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) III (DNA directed) polypeptide B
|
| Other Description |
DNA-directed RNA polymerase III 127.6 kDa polypeptide|DNA-directed RNA polymerase III subunit B|DNA-directed RNA polymerase III subunit RPC2|RNA polymerase III subunit C2|interphase nucleus and mitotic apparatus associated protein
|
| Swissprots |
B3KV73 Q9NW08 A8K6H0 Q9NW59 F5H1E6
|
| Accessions |
EAW97780 EAW97781 Q9NW08 AK001161 BAA91527 AK001250 BAA91581 AK090636 BAG52201 AK092031 BAG52470 AK122713 BAG53685 AK291635 BAF84324 AY092084 AAM18214 BC017501 BC033542 BC033724 BC046238 AAH46238 BX537447 CAD97689 BX648712 DA236776 DB094040 KJ818092 AIJ28481 NM_001160708 NP_001154180 NM_018082 NP_060552
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000250, ECO:000026
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|