POLR3B

Gene Symbol	POLR3B
Entrez Gene	55703
Alt Symbol	C128, HLD8, INMAP, RPC2
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) III (DNA directed) polypeptide B
Other Description	DNA-directed RNA polymerase III 127.6 kDa polypeptide|DNA-directed RNA polymerase III subunit B|DNA-directed RNA polymerase III subunit RPC2|RNA polymerase III subunit C2|interphase nucleus and mitotic apparatus associated protein
Swissprots	B3KV73 Q9NW08 A8K6H0 Q9NW59 F5H1E6
Accessions	EAW97780 EAW97781 Q9NW08 AK001161 BAA91527 AK001250 BAA91581 AK090636 BAG52201 AK092031 BAG52470 AK122713 BAG53685 AK291635 BAF84324 AY092084 AAM18214 BC017501 BC033542 BC033724 BC046238 AAH46238 BX537447 CAD97689 BX648712 DA236776 DB094040 KJ818092 AIJ28481 NM_001160708 NP_001154180 NM_018082 NP_060552
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000250, ECO:000026
Subcellular Location	Nucleus {ECO:0000250}.
Top Pathways	Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human POLR3B protein fragment - ab163185 from Abcam Category Protein Source Wheat germ Species Human

POLR3B Antibody Blocking Peptide - LS-E2732 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

POLR3B Antibody Blocking Peptide - LS-E17649 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human POLR3B Protein - H00055703-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

POLR3B-Antibody-N-term-Blocking-peptide - BP13819a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

POLR3B Blocking Peptide - 33R-3943 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

POLR3B / RPC2 - H00055703-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

POLR3B / RPC2 - H00055703-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

POLR3B fusion protein - ag9856 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

POLR3B fusion protein - Ag10076 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human DNA-directed RNA polymerase III subunit RPC2(POLR3B) ,partial - CSB-YP885742HU CSB-EP885742HU CSB-BP885742HU CSB-MP885742HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

POLR3B Blocking Peptide - abx061293 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Monkey, Pig, Rabbit, Zebrafish

POLR3B Recombinant Protein Antigen - NBP1-84628PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

POLR3B Peptide, Human - M34GP12105H from Creative Peptides Category Peptide Source Synthetic. Species Human

POLR3B Blocking Peptide - CBP5206 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Monkey, Pig, Rabbit, Zebrafish

DNA-directed RNA polymerase III subunit RPC2 (POLR3B), partial, Recombinant Protein - MBS1287885 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

POLR3B peptide - orb319352 from Biorbyt Category Peptide

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