POLR3B

Gene Symbol POLR3B
Entrez Gene 55703
Alt Symbol C128, HLD8, INMAP, RPC2
Species Human
Gene Type protein-coding
Description polymerase (RNA) III (DNA directed) polypeptide B
Other Description DNA-directed RNA polymerase III 127.6 kDa polypeptide|DNA-directed RNA polymerase III subunit B|DNA-directed RNA polymerase III subunit RPC2|RNA polymerase III subunit C2|interphase nucleus and mitotic apparatus associated protein
Swissprots B3KV73 Q9NW08 A8K6H0 Q9NW59 F5H1E6
Accessions EAW97780 EAW97781 Q9NW08 AK001161 BAA91527 AK001250 BAA91581 AK090636 BAG52201 AK092031 BAG52470 AK122713 BAG53685 AK291635 BAF84324 AY092084 AAM18214 BC017501 BC033542 BC033724 BC046238 AAH46238 BX537447 CAD97689 BX648712 DA236776 DB094040 KJ818092 AIJ28481 NM_001160708 NP_001154180 NM_018082 NP_060552
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000250, ECO:000026
Subcellular Location Nucleus {ECO:0000250}.
Top Pathways Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

POLR3B (S-13) - sc-109402 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
POLR3B (S-13): sc-109402. Western blot analysis of POLR3B expression in HEL 92.1.7 nuclear extract.

POLR3B (N-15) - sc-109401 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
POLR3B (N-15): sc-109401. Western blot analysis of POLR3B expression in HEK293 (A) and HeLa (B) whole cell lysates.

POLR3B (K-14) - sc-109400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-POLR3B antibody - ab86143 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling POLR3B with ab86143 at 1/1000 (0.2µg/ml). Detection: DAB.

Anti-POLR3B antibody - ab75063 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-POLR3B antibody (ab75063) at 1/500 dilutionLane 1 : extracts from LOVO cellsLane 2 : extracts from LOVO cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-POLR3B antibody - ab114967 from Abcam

Prices $428.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab114967 at 1/250 dilution staining POLR3B in Formalin-fixed, Paraffin-embedded Human Hodgkin's Lymphoma tissue by Immunohistochemistry. Detection: DAB staining.

Anti-POLR3B antibody [EPR8719] - ab137030 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8719
All lanes : Anti-POLR3B antibody [EPR8719] (ab137030) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : Hela cell lysateLane 3 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP conjugated Goat anti Rabbit IgG at 1/2000 dilution

Anti-POLR3B Antibody (aa330-359) - LS-C163856 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
POLR3B Antibody western blot of mouse spleen tissue lysates (35 ug/lane). The POLR3B antibody detected the POLR3B protein (arrow).

Anti-POLR3B Antibody - LS-C178484 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-POLR3B Antibody (aa321-370) - LS-C119918 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from LOVO cells, using RPC2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-POLR3B Antibody (aa1083-1133) - LS-C288630 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human RPC2 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-RPC2 used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.

Anti-POLR3B Antibody (aa1083-1133) - LS-C286666 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human RPC2 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-RPC2 used at a dilution of 1:500.

Anti-POLR3B Antibody (aa329-359) - LS-C324173 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR3B Antibody (aa866-915) - LS-C81302 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal heart lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6%-18%.

POLR3B Antibody - NBP1-54363 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: POLR3B Antibody [NBP1-54363] - Human Heart lysate, concentration 0.2-1 ug/ml.

POLR3B Antibody - NBP1-84628 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

POLR3B Antibody (3G10) - H00055703-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G10
ELISA: POLR3B Antibody (3G10) [H00055703-M01] - Detection limit for recombinant GST tagged POLR3B is 0.1 ng/ml as a capture antibody.

Monoclonal Anti-POLR3B antibody produced in mouse - SAB1403299 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G10
<B>Immunoblotting</B><BR/>Monoclonal Anti-POLR3B: <B>Cat. No. SAB1403299</B>: Antibody concentration: 1 μg/mL. Specific band of ~37 kDa using immunogen protein lysate.

Anti-POLR3B antibody produced in rabbit - HPA036466 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-POLR3B: <B>Cat. No. HPA036466</B>: Immunohistochemical staining of human rectum shows strong nuclear/ or nucleolar positivity in glandular cells.

Anti-POLR3B antibody produced in rabbit - AV48821 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: fetal heart (<B>Cat. No. AV48821</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type fetal heart

POLR3B antibody - C-terminal region (ARP48821_P050) - ARP48821_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

POLR3B-Antibody-N-term - AP13819a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
POLR3B Antibody (N-term) (Cat. #AP13819a) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the POLR3B antibody detected the POLR3B protein (arrow).

POLR3B Antibody - N-terminal region (OAAB10117) - OAAB10117 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

POLR3B Antibody (OAAF03588) - OAAF03588 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

POLR3B antibody - orb77855 from Biorbyt

Prices $425.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of 293T cell and fetal liver lysate using POLR3B antibody
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