CHI3L1

Gene Symbol CHI3L1
Entrez Gene 1116
Alt Symbol ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39
Species Human
Gene Type protein-coding
Description chitinase 3-like 1 (cartilage glycoprotein-39)
Other Description 39 kDa synovial protein|cartilage glycoprotein 39|chitinase-3-like protein 1
Swissprots Q8IVA4 B2R7B0 P30923 Q96HI7 P36222
Accessions CAA69661 CAB76472 EAW91467 EAW91468 P36222 AB209459 BAD92696 AK095458 BAG53058 AK130142 AK130200 AK225266 AK225584 AK312911 BAG35757 BC008568 AAH08568 BC034684 BC038354 AAH38354 BC039132 AAH39132 BT007223 AAP35887 BX648308 DA167112 DQ890777 ABM81703 DQ893937 ABM84863 EU831608 ACE87208 EU831695 ACE86529 M80927 AAA16074 XM_011509105 XP_011507407 XM_011509106 XP_011507408 XM_011509107 XP_011507409 XM_011509108 XP_011507410 NM_001276 NP_001267
Function Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:9492324}.
Subcellular Location Secreted, extracellular space {ECO:0000269|PubMed:9492324}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Tissue Specificity Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:9492324}.

GP-39 (A-10) - sc-393590 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GP-39 (A-10): sc-393590. Western blot analysis of GP-39 expression in non-transfected: sc-117752 (A) and human GP-39 transfected: sc-113587 (B) 293T whole cell lysates.

GP-39 (D-11) - sc-393494 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GP-39 (D-11): sc-393494. Western blot analysis of GP-39 expression in non-transfected 293: sc-110760 (A), human GP-39 transfected 293: sc-110933 (B), Jurkat (C) and THP-1 (D) whole cell lysates.

GP-39 (E-10) - sc-393476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GP-39 (E-10): sc-393476. Western blot analysis of GP-39 expression in non-transfected: sc-110760 (A) and human GP-39 transfected: sc-110933 (B) 293 whole cell lysates and human liver tissue extract (C).

GP-39 (H-46) - sc-98955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GP-39 (H-46): sc-98955. Western blot analysis of GP-39 expression in Hep G2 (A), THP-1 (B) and HeLa (C) whole cell lysates.

GP-39 (N-15) - sc-31722 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GP-39 (N-15): sc-31722. Western blot analysis of GP-39 expression in mouse (A) and rat (B) liver tissue extracts.

GP-39 (N-16) - sc-30464 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GP-39 (S-18) - sc-30465 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GP-39 (S-18): sc-30465. Western blot analysis of GP-39 expression in non-transfected: sc-110760 (A) and human GP-39 transfected: sc-110933 (B) 293 whole cell lysates.

Anti-CHI3L1 antibody - ab77528 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CHI3L1 antibody (ab77528) at 1 µg/ml + THP1 (Human acute monocytic leukemia cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CHI3L1 antibody - ab180569 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CHI3L1 antibody (ab180569) at 1/500 dilution + TPH1 cell extracts

Anti-CHI3L1 antibody - ab193440 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHI3L1 antibody [AT4A3] - ab86428 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone AT4A3
Anti-CHI3L1 antibody [AT4A3] (ab86428) at 1/250 dilution + HepG2 cell lysates at 35 µgSecondaryGoat anti-mouse secondary antibody conjugated to HRPdeveloped using the ECL technique

Anti-CHI3L1 antibody [MM0628-9X24] - ab135148 from Abcam

Prices $370.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone MM0628-9X24

Anti-CHI3L1 / YKL-40 Antibody - LS-C341134 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CHI3L1 / YKL-40 Antibody (aa112-356) - LS-C294301 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CHI3L1 / YKL-40.

Anti-CHI3L1 / YKL-40 Antibody (aa112-377) - LS-C294299 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CHI3L1 / YKL-40.

Anti-CHI3L1 / YKL-40 Antibody (aa112-377, FITC) - LS-C302571 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CHI3L1 / YKL-40.

Anti-CHI3L1 / YKL-40 Antibody - LS-C331657 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of THP1 cell lines, using CHI3L1 antibody.

Anti-CHI3L1 / YKL-40 Antibody - LS-C332391 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human liver cancer using CHI3L1 antibody at dilution of 1:200 (x400 lens).

Anti-CHI3L1 / YKL-40 Antibody (aa198-247) IHC-plus™ - LS-B8213 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-YKL-40 / CHI3L1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8213 dilution 2.5-5 ug/ml.

Anti-CHI3L1 / YKL-40 Antibody (aa22-383) - LS-C125352 from LifeSpan Bioscience

Prices $375.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal

Anti-CHI3L1 / YKL-40 Antibody (aa314-344, APC) - LS-C254733 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CHI3L1 / YKL-40 Antibody (aa314-344, AP) - LS-C254732 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CHI3L1 / YKL-40 Antibody (aa314-344, Biotin) - LS-C254734 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CHI3L1 / YKL-40 Antibody (aa314-344, Azide-free, HRP) - LS-C254737 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CHI3L1 / YKL-40 Antibody (aa314-344, FITC) - LS-C254735 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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