CHI3L1

Gene Symbol	CHI3L1
Entrez Gene	1116
Alt Symbol	ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39
Species	Human
Gene Type	protein-coding
Description	chitinase 3-like 1 (cartilage glycoprotein-39)
Other Description	39 kDa synovial protein|cartilage glycoprotein 39|chitinase-3-like protein 1
Swissprots	Q8IVA4 B2R7B0 P30923 Q96HI7 P36222
Accessions	CAA69661 CAB76472 EAW91467 EAW91468 P36222 AB209459 BAD92696 AK095458 BAG53058 AK130142 AK130200 AK225266 AK225584 AK312911 BAG35757 BC008568 AAH08568 BC034684 BC038354 AAH38354 BC039132 AAH39132 BT007223 AAP35887 BX648308 DA167112 DQ890777 ABM81703 DQ893937 ABM84863 EU831608 ACE87208 EU831695 ACE86529 M80927 AAA16074 XM_011509105 XP_011507407 XM_011509106 XP_011507408 XM_011509107 XP_011507409 XM_011509108 XP_011507410 NM_001276 NP_001267
Function	Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:9492324}.
Subcellular Location	Secreted, extracellular space {ECO:0000269|PubMed:9492324}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Tissue Specificity	Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:9492324}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CHI3L1 full length protein - ab182706 from Abcam Category Protein Prices $536.00 Sizes 100 µg Source HEK 293 cells Species Human

Human CHI3L1 full length protein - ab151938 from Abcam Category Protein Source HEK 293 cells Species Human

Human CHI3L1 full length protein - ab152274 from Abcam Category Protein Source Wheat germ Species Human

Human CHI3L1 full length protein - ab140057 from Abcam Category Protein Source CHO Species Human

Human CHI3L1 peptide - ab88218 from Abcam Category Peptide

Human CHI3L1 peptide - ab88962 from Abcam Category Peptide

CHI3L1 / YKL-40 Antibody Blocking Peptide - LS-E18632 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Chitinase 3-like 1, CF - 2599-CH-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Tyr22-Thr383, with a C-terminal 6-His tag

CHI3L1 Protein Lysate (APL10879) - APL10879 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human CHI3L1 Enzyme - orb191407 from Biorbyt Category Protein Prices $230.00, $442.00, $1,811.00 Sizes 1 μg, 5 μg, 50 μg Source CHO (chinese hamster ovary cells). Species Human

Human CHI3L1 His tag protein - orb83533 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

CHI3L1 Blocking Peptide - 33R-4844 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human GP39 Protein - abx066883 from Abbexa Category Protein Source E.coli Species Human

YKL-40 Blocking Peptide - abx161236 from Abbexa Category Peptide Species Human, Mouse, Rat

CHI3L1 (1-383, His-tag) - AR50786PU-N from Acris Antibodies Category Protein Prices $590.00 Sizes 50 µg Species Human

CHI3L1 (1-383, His-tag) - AR50786PU-S from Acris Antibodies Category Protein Prices $255.00 Sizes 10 µg Species Human

CHI3L1, 1-383aa Human, His tag, CHO - 01-P1962 from ARP American Research Products Category Protein Prices $109.00, $259.00, $639.00 Sizes 2 µg, 10 µg, 50 µg Species Human

Chitinase-3-Like Protein 1, CHI3L1, Human, Recombinant - 19-C452 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

Glycoprotein 39, Cartilage (GP39), Human - 20-7731 from ARP American Research Products Category Protein Prices $485.00 Sizes 50 µg Source E.coli Species Human

CGP 39 Recombinant Protein - 96-186 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

CHI3L1 fusion protein - ag2710 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CHI3L1 Protein - BP001691-C452 from Syd Labs Category Protein Prices $98.00, $264.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human CHI3L1, His tagged - CHI3L1-657H from Creative Biomart Category Protein Source Human Cells Species Human

CHI3L1 - PN201295 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

Recombinant Glycoprotein 39, Cartilage (GP39) - RPB463Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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