| Gene Symbol |
CHI3L1
|
| Entrez Gene |
1116
|
| Alt Symbol |
ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chitinase 3-like 1 (cartilage glycoprotein-39)
|
| Other Description |
39 kDa synovial protein|cartilage glycoprotein 39|chitinase-3-like protein 1
|
| Swissprots |
Q8IVA4 B2R7B0 P30923 Q96HI7 P36222
|
| Accessions |
CAA69661 CAB76472 EAW91467 EAW91468 P36222 AB209459 BAD92696 AK095458 BAG53058 AK130142 AK130200 AK225266 AK225584 AK312911 BAG35757 BC008568 AAH08568 BC034684 BC038354 AAH38354 BC039132 AAH39132 BT007223 AAP35887 BX648308 DA167112 DQ890777 ABM81703 DQ893937 ABM84863 EU831608 ACE87208 EU831695 ACE86529 M80927 AAA16074 XM_011509105 XP_011507407 XM_011509106 XP_011507408 XM_011509107 XP_011507409 XM_011509108 XP_011507410 NM_001276 NP_001267
|
| Function |
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:9492324}.
|
| Subcellular Location |
Secreted, extracellular space {ECO:0000269|PubMed:9492324}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
|
| Tissue Specificity |
Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:9492324}.
|