| Gene Symbol |
CCL25
|
| Entrez Gene |
6370
|
| Alt Symbol |
Ckb15, SCYA25, TECK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) ligand 25
|
| Other Description |
C-C motif chemokine 25|Ck beta-15|TECKvar|chemokine TECK|small inducible cytokine subfamily A (Cys-Cys), member 25|small-inducible cytokine A25|thymus expressed chemokine|thymus-expressed chemokine
|
| Swissprots |
A6NI52 A1L4J4 Q96KJ7 B5MCA5 O15444 A8K9E7
|
| Accessions |
EAW68951 EAW68952 O15444 AB046579 BAB62257 AI313430 AI961745 AK292662 BAF85351 BC125136 AAI25137 BC130561 AAI30562 BC144463 AAI44464 HQ258070 ADR82824 U86358 AAB69981 XM_011528177 XP_011526479 NM_001201359 NP_001188288 NM_005624 NP_005615 NM_148888
|
| Function |
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Chemokine signaling pathway
|
![Western Blot: TECK Overexpression Lysate (Adult Normal) [NBP2-10453] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TECK.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2202_TECK%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10453-img0001.jpg)