Gene Symbol | CCL25 |
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Entrez Gene | 6370 |
Alt Symbol | Ckb15, SCYA25, TECK |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 25 |
Other Description | C-C motif chemokine 25|Ck beta-15|TECKvar|chemokine TECK|small inducible cytokine subfamily A (Cys-Cys), member 25|small-inducible cytokine A25|thymus expressed chemokine|thymus-expressed chemokine |
Swissprots | A6NI52 A1L4J4 Q96KJ7 B5MCA5 O15444 A8K9E7 |
Accessions | EAW68951 EAW68952 O15444 AB046579 BAB62257 AI313430 AI961745 AK292662 BAF85351 BC125136 AAI25137 BC130561 AAI30562 BC144463 AAI44464 HQ258070 ADR82824 U86358 AAB69981 XM_011528177 XP_011526479 NM_001201359 NP_001188288 NM_005624 NP_005615 NM_148888 |
Function | Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
Subcellular Location | Secreted. |
Tissue Specificity | Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine. |
Top Pathways | Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Chemokine signaling pathway |
TECK CRISPR/Cas9 KO Plasmid (h) - sc-409682 from Santa Cruz Biotechnology
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TECK HDR Plasmid (h) - sc-409682-HDR from Santa Cruz Biotechnology
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TECK Double Nickase Plasmid (h) - sc-409682-NIC from Santa Cruz Biotechnology
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TECK Double Nickase Plasmid (h2) - sc-409682-NIC-2 from Santa Cruz Biotechnology
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TECK CRISPR Activation Plasmid (h) - sc-409682-ACT from Santa Cruz Biotechnology
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TECK CRISPR Activation Plasmid (h2) - sc-409682-ACT-2 from Santa Cruz Biotechnology
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TECK Lentiviral Activation Particles (h) - sc-409682-LAC from Santa Cruz Biotechnology
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TECK Lentiviral Activation Particles (h2) - sc-409682-LAC-2 from Santa Cruz Biotechnology
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TECK siRNA (h) - sc-39371 from Santa Cruz Biotechnology
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TECK shRNA Plasmid (h) - sc-39371-SH from Santa Cruz Biotechnology
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TECK shRNA (h) Lentiviral Particles - sc-39371-V from Santa Cruz Biotechnology
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CCL25/TECK RNAi - H00006370-R01 from Novus Biologicals
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MISSION® esiRNA - EHU099021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5611 from Sigma-Aldrich
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CCL25 siRNA (Human) - CRH4302 from Cohesion Biosciences
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CCL25 - MBS8207116 from MyBioSource
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shRNA set against Human Ccl25 (NM_005624.3) - SHH257605 from Creative biogene
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Human CCL25 siRNA - orb264804 from Biorbyt
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CCL25 shRNA Plasmid (Human) - CHH4302 from Cohesion Biosciences
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CCL25 miRNA 3'UTR clone - MiUTR4H-TG01811 from Creative biogene
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