| Gene Symbol |
CAV1
|
| Entrez Gene |
281040
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
caveolin 1, caveolae protein, 22kDa
|
| Other Description |
caveolin-1
|
| Swissprots |
P79132 Q5PX19 A4D7R5
|
| Accessions |
AAR16256 DAA30606 P79132 AY823915 AAV83691 BC103050 AAI03051 U86639 AAB47274 XM_005205391 XP_005205448 XM_005205392 XP_005205449 XM_010804191 XP_010802493 XM_010804192 XP_010802494 NM_174004 NP_776429
|
| Function |
Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
|
| Top Pathways |
Focal adhesion, Endocytosis, Bacterial invasion of epithelial cells, Proteoglycans in cancer
|