AP3B2

Gene Symbol AP3B2
Entrez Gene 8120
Alt Symbol NAPTB
Species Human
Gene Type protein-coding
Description adaptor-related protein complex 3, beta 2 subunit
Other Description AP-3 complex subunit beta-2|Neuronal adaptin-like protein, beta-subunit|adapter-related protein complex 3 subunit beta-2|adaptor protein complex AP-3 subunit beta-2|adaptor-related protein complex 3 subunit beta-2|beta-3B-adaptin|clathrin assembly protein complex 3 beta-2 large chain|neuron-specific vesicle coat protein beta-NAP
Swissprots Q52LY8 O14808 A4Z4T7 B7ZKS0 B7ZKR7 Q13367
Accessions EAW62447 Q13367 AF022152 AAB71894 AK097827 BAG53536 AK294331 BAG57603 BC008350 BC026700 BC035640 BC093739 AAH93739 BC143342 AAI43343 BC143346 AAI43347 BI914720 BQ777385 CR749860 CAH18704 DQ092369 AAZ38147 U37673 AAC50219 XM_011522097 XP_011520399 XM_011522098 XP_011520400 XM_011522099 XP_011520401 XM_011522100 XP_011520402 NM_001278511 NP_001265440 NM_001278512 NP_001265441 NM_004644 NP_004635
Function Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular Location Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Tissue Specificity Expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression). {ECO:0000269|PubMed:1851215}.
Top Pathways Lysosome

β-NAP (C-15) - sc-13391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

β-NAP (T-17) - sc-13390 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-AP3B2 antibody - ab113100 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of AP3B2 in mouse brain tissue with ab113100 at 20 ug/mL.

Anti-AP3B2 antibody - ab48269 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AP3B2 antibody (ab48269) at 1/500 dilution

Anti-AP3B2 antibody - ab14227 from Abcam

Prices $406.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Immunocytochemistry staining of endogenous AP3B2 in AtT-20 cells. ab14227 dilution: 1/200; Donkey anti-IgY Fc-FITC: 1/200.

Anti-AP3B2 antibody - ab130690 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-AP3B2 antibody (ab130690) at 1/100 dilution + 293 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-AP3B2 antibody - N-terminal - ab174734 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cortex tissue labeling AP3B2 with ab174734 at 5 µg/ml.

Anti-AP3B2 Antibody (aa16-44, AP) - LS-C251467 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP3B2 Antibody (aa16-44, APC) - LS-C251468 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP3B2 Antibody (aa16-44, FITC) - LS-C251470 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP3B2 Antibody (aa16-44, Biotin) - LS-C251469 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP3B2 Antibody (aa16-44, Azide-free, HRP) - LS-C251471 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP3B2 Antibody (aa16-44, PE) - LS-C251472 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP3B2 Antibody (aa15-44) - LS-C319515 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP3B2 Antibody (aa16-44) - LS-C156390 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
AP3B2 Antibody western blot of 293 cell line lysates (35 ug/lane). The AP3B2 antibody detected the AP3B2 protein (arrow).

Anti-AP3B2 Antibody (N-Terminus) IHC-plus™ - LS-B8797 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-AP3B2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

AP3B2 Antibody - NBP1-76590 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: AP3B2 Antibody [NBP1-76590] - Analysis of AP3B2 in rat brain tissue lysate with AP3B2 antibody at (A) 1 and (B) 2 ug/mL.

AP3B2 Antibody - NBP1-81011 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

AP3B2 Antibody - NB120-14227 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: AP3B2 Antibody [NB120-14227] - ICC: Immunocytochemistry staining of endogenous AP3B2 in AtT-20 cells. Anti-AP3B2 IgY dilution: 1:200; Donkey anti-IgY Fc-FITC: 1:200. ( anti-AP3B2 )

AP3B2 Antibody - NB100-74370 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: AP3B2 Antibody [NB100-74370] - Figure 1 illustrates Western blot detection of beta-NAP at ~125 kDa using NB100-74370. A ~50 kDa band is also seen in rat and mouse brain tissue, representing the medium chain homolog (p47A) of AP3.

Anti-APEB2 antibody produced in chicken - GW21448A from Sigma-Aldrich

Prices $267.50
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-AP3B2 antibody produced in rabbit - HPA039467 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AP3B2: <B>Cat. No. HPA039467</B>: Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.

Anti-AP3B2 (16-30) antibody produced in rabbit - SAB1105060 from Sigma-Aldrich

Prices $279.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP3B2 antibody produced in rabbit - HPA039818 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AP3B2: <B>Cat. No. HPA039818</B>: Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

AP3B2-Antibody-N-term - AP16877a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
AP3B2 Antibody (N-term) (Cat. #AP16877a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AP3B2 antibody detected the AP3B2 protein (arrow).
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