AP3B2

Gene Symbol	AP3B2
Entrez Gene	8120
Alt Symbol	NAPTB
Species	Human
Gene Type	protein-coding
Description	adaptor-related protein complex 3, beta 2 subunit
Other Description	AP-3 complex subunit beta-2|Neuronal adaptin-like protein, beta-subunit|adapter-related protein complex 3 subunit beta-2|adaptor protein complex AP-3 subunit beta-2|adaptor-related protein complex 3 subunit beta-2|beta-3B-adaptin|clathrin assembly protein complex 3 beta-2 large chain|neuron-specific vesicle coat protein beta-NAP
Swissprots	Q52LY8 O14808 A4Z4T7 B7ZKS0 B7ZKR7 Q13367
Accessions	EAW62447 Q13367 AF022152 AAB71894 AK097827 BAG53536 AK294331 BAG57603 BC008350 BC026700 BC035640 BC093739 AAH93739 BC143342 AAI43343 BC143346 AAI43347 BI914720 BQ777385 CR749860 CAH18704 DQ092369 AAZ38147 U37673 AAC50219 XM_011522097 XP_011520399 XM_011522098 XP_011520400 XM_011522099 XP_011520401 XM_011522100 XP_011520402 NM_001278511 NP_001265440 NM_001278512 NP_001265441 NM_004644 NP_004635
Function	Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular Location	Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Tissue Specificity	Expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression). {ECO:0000269|PubMed:1851215}.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse AP3B2 peptide - ab48404 from Abcam Category Peptide Species Mouse

AP3B2 Antibody Blocking Peptide - LS-E4537 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AP3B2 Antibody Blocking Peptide - LS-E31137 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

AP3B2 Blocking Peptide - NBP1-76590PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

AP3B2-Antibody-N-term-Blocking-Peptide - BP16877a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AP3 complex subunit beta-2 control peptide - AP26159CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

AP3B2 Peptide - 6395P from ProSci Category Peptide Species Human

AP3B2 fusion protein - Ag13021 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

AP3B2 fusion protein - Ag12861 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human AP3B2, GST-tagged - AP3B2-9720H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human AP-3 complex subunit beta-2(AP3B2) ,partial - CSB-YP621662HU CSB-EP621662HU CSB-BP621662HU CSB-MP621662HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

AP-3 complex subunit beta-2(AP3B2) ,partial, Recombinant Protein - MBS1379081 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

AP3B2 Recombinant Protein Antigen - NBP1-81012PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

AP3B2 Recombinant Protein Antigen - NBP1-81011PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

AP3B2 Peptide, Human - M34GP00723H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human AP3B2 protein, His-tagged - AP3B2-920H from Creative Biomart Category Protein Source E.coli Species Human

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