| Gene Symbol |
AP3B2
|
| Entrez Gene |
8120
|
| Alt Symbol |
NAPTB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adaptor-related protein complex 3, beta 2 subunit
|
| Other Description |
AP-3 complex subunit beta-2|Neuronal adaptin-like protein, beta-subunit|adapter-related protein complex 3 subunit beta-2|adaptor protein complex AP-3 subunit beta-2|adaptor-related protein complex 3 subunit beta-2|beta-3B-adaptin|clathrin assembly protein complex 3 beta-2 large chain|neuron-specific vesicle coat protein beta-NAP
|
| Swissprots |
Q52LY8 O14808 A4Z4T7 B7ZKS0 B7ZKR7 Q13367
|
| Accessions |
EAW62447 Q13367 AF022152 AAB71894 AK097827 BAG53536 AK294331 BAG57603 BC008350 BC026700 BC035640 BC093739 AAH93739 BC143342 AAI43343 BC143346 AAI43347 BI914720 BQ777385 CR749860 CAH18704 DQ092369 AAZ38147 U37673 AAC50219 XM_011522097 XP_011520399 XM_011522098 XP_011520400 XM_011522099 XP_011520401 XM_011522100 XP_011520402 NM_001278511 NP_001265440 NM_001278512 NP_001265441 NM_004644 NP_004635
|
| Function |
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
|
| Subcellular Location |
Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
|
| Tissue Specificity |
Expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression). {ECO:0000269|PubMed:1851215}.
|
| Top Pathways |
Lysosome
|
