| Gene Symbol |
IL1RL1
|
| Entrez Gene |
9173
|
| Alt Symbol |
DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 1 receptor-like 1
|
| Other Description |
growth stimulation-expressed|homolog of mouse growth stimulation-expressed|interleukin 1 receptor-related protein|interleukin-1 receptor-like 1
|
| Swissprots |
A8K6B3 Q9ULV7 Q01638 B4E0I3 Q8NEJ3 Q9UQ44 Q53TU7
|
| Accessions |
AAY15047 BAA20539 EAX01795 Q01638 AB012701 BAA82405 AB029084 BAA85894 AK291578 BAF84267 AK303389 BAG64445 AL117622 AL553735 AM392936 CAL37814 BC012580 BC030975 AAH30975 BQ012352 D12763 BAA02233 DA884586 DB063031 EU181431 ABW33704 EU181432 ABW33705 XM_006712839 XP_006712902 XM_011512151 XP_011510453 NM_001282408 NP_001269337 NM_003856 NP_003847 NM_016232 NP_057316 NR_104167 NM_173459
|
| Function |
Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. {ECO:0000269|PubMed:16286016}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:11478810}; Single-pass type I membrane protein {ECO:0000269|PubMed:11478810}.
|
| Tissue Specificity |
Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. {ECO:0000269|PubMed:11478810}.
|