Gene Symbol | IL1RL1 |
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Entrez Gene | 9173 |
Alt Symbol | DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 |
Species | Human |
Gene Type | protein-coding |
Description | interleukin 1 receptor-like 1 |
Other Description | growth stimulation-expressed|homolog of mouse growth stimulation-expressed|interleukin 1 receptor-related protein|interleukin-1 receptor-like 1 |
Swissprots | A8K6B3 Q9ULV7 Q01638 B4E0I3 Q8NEJ3 Q9UQ44 Q53TU7 |
Accessions | AAY15047 BAA20539 EAX01795 Q01638 AB012701 BAA82405 AB029084 BAA85894 AK291578 BAF84267 AK303389 BAG64445 AL117622 AL553735 AM392936 CAL37814 BC012580 BC030975 AAH30975 BQ012352 D12763 BAA02233 DA884586 DB063031 EU181431 ABW33704 EU181432 ABW33705 XM_006712839 XP_006712902 XM_011512151 XP_011510453 NM_001282408 NP_001269337 NM_003856 NP_003847 NM_016232 NP_057316 NR_104167 NM_173459 |
Function | Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. {ECO:0000269|PubMed:16286016}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:11478810}; Single-pass type I membrane protein {ECO:0000269|PubMed:11478810}. |
Tissue Specificity | Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. {ECO:0000269|PubMed:11478810}. |
ST2 CRISPR/Cas9 KO Plasmid (h) - sc-402390 from Santa Cruz Biotechnology
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ST2 HDR Plasmid (h) - sc-402390-HDR from Santa Cruz Biotechnology
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ST2 Double Nickase Plasmid (h) - sc-402390-NIC from Santa Cruz Biotechnology
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ST2 Double Nickase Plasmid (h2) - sc-402390-NIC-2 from Santa Cruz Biotechnology
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ST2 CRISPR Activation Plasmid (h) - sc-402390-ACT from Santa Cruz Biotechnology
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ST2 CRISPR Activation Plasmid (h2) - sc-402390-ACT-2 from Santa Cruz Biotechnology
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ST2 Lentiviral Activation Particles (h) - sc-402390-LAC from Santa Cruz Biotechnology
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ST2 Lentiviral Activation Particles (h2) - sc-402390-LAC-2 from Santa Cruz Biotechnology
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ST2 siRNA (h) - sc-40035 from Santa Cruz Biotechnology
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ST2 shRNA Plasmid (h) - sc-40035-SH from Santa Cruz Biotechnology
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ST2 shRNA (h) Lentiviral Particles - sc-40035-V from Santa Cruz Biotechnology
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IL1RL1 RNAi - H00009173-R05 from Novus Biologicals
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IL1RL1 RNAi - H00009173-R04 from Novus Biologicals
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MISSION® esiRNA - EHU158921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10601 from Sigma-Aldrich
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IL1RL1 siRNA (Human) - CRH6070 from Cohesion Biosciences
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IL1RL1 RNAi - H00009173-R06 from Novus Biologicals
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IL1RL1 - MBS8204705 from MyBioSource
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shRNA set against Human Il1rl1 (NM_016232.4) - SHH318605 from Creative biogene
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shRNA set against Human IL1RL1(NM_016232.4) - SHL037684 from Creative biogene
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shRNA set against Human IL1RL1(NM_003856.2) - SHL037720 from Creative biogene
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Human ST2 siRNA - orb266572 from Biorbyt
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IL1RL1 shRNA Plasmid (Human) - CHH6070 from Cohesion Biosciences
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IL1RL1 miRNA 3'UTR clone - MiUTR1H-04900 from Creative biogene
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