Gene Symbol | CRY1 |
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Entrez Gene | 1407 |
Alt Symbol | PHLL1 |
Species | Human |
Gene Type | protein-coding |
Description | cryptochrome circadian clock 1 |
Other Description | cryptochrome 1 (photolyase-like)|cryptochrome-1 |
Swissprots | Q16526 |
Accessions | ABM64209 EAW97795 EAW97796 EAW97797 Q16526 AK098615 BAC05354 AK125915 AK290552 BAF83241 BC017466 BC030519 AAH30519 BJ993835 D83702 BAA12068 D84657 BAA12710 DB454192 JF432699 ADZ15916 XM_011537939 XP_011536241 NM_004075 NP_004066 |
Function | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and |
Subcellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:P97784}. Note=Translocated to the nucleus through interaction with other clock proteins such as PER2 or ARNTL/BMAL1. {ECO:0000250}. |
Top Pathways | Circadian rhythm |
Cryptochrome I peptide - ab5005 from Abcam
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Human Cryptochrome I full length protein - ab114543 from Abcam
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CRY1 Antibody Blocking Peptide - LS-E25164 from LifeSpan Bioscience
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CRY1 Antibody Blocking Peptide - LS-E8089 from LifeSpan Bioscience
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Recombinant Human CRY1 Protein - H00001407-P01 from Novus Biologicals
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Cryptochrome I Peptide - P1742 from Novus Biologicals
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Cry1-Antibody-C-term-Blocking-Peptide - BP6134a from Abgent, a WuXi AppTec company
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Bt Cry1Ab protein - 30R-AB018 from Fitzgerald
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Cryptochrome-1 - H00001407-P01-10 from Acris Antibodies
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Cryptochrome-1 - H00001407-P01-25 from Acris Antibodies
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Cryptochrome-1 control peptide - SP5220CP from Acris Antibodies
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CRY1 fusion protein - Ag14472 from Proteintech Group
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CRY1 fusion protein - Ag4270 from Proteintech Group
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Recombinant Human CRY1 - CRY1-26414TH from Creative Biomart
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Recombinant Human CRY1, His-tagged - CRY1-11596H from Creative Biomart
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Recombinant Cryptochrome 1 (CRY1) - RPC407Hu01 from Uscn Life Science Inc.
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Recombinant Cryptochrome 1 (CRY1) - RPC407Hu01 from Cloud-clone
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Recombinant Human Cryptochrome-1(CRY1) - CSB-YP621957HU CSB-EP621957HU CSB-BP621957HU CSB-MP621957HU from Cusabio
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CRY1 Protein - abx164941 from Abbexa
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CRY1 Protein - abx163796 from Abbexa
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Cryptochrome-1 - TP307152 from Acris Antibodies
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Recombinant Human CRY1 protein, MYC/DDK-tagged - CRY1-7269H from Creative Biomart
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CRY1 Peptide, Human - M34GP03669H from Creative Peptides
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CRY1 Blocking Peptide - NBP1-69080PEP from Novus Biologicals
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CRY1 Recombinant Protein (OPCD02439) - OPCD02439 from Aviva Systems Biology
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